Qi Yongli, Kang Seung-Kyun, Fang Hui
Thayer School of Engineering, Dartmouth College, Hanover, USA.
Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea.
MRS Bull. 2023 May;48(5):475-483. doi: 10.1557/s43577-023-00540-5. Epub 2023 May 24.
Materials innovation has arguably played one of the most important roles in the development of implantable neuroelectronics. Such technologies explore biocompatible working systems for reading, triggering, and manipulating neural signals for neuroscience research and provide the additional potential to develop devices for medical diagnostics and/or treatment. The past decade has witnessed a golden era in neuroelectronic materials research. For example, R&D on soft material-based devices have exploded and taken center stage for many applications, including both central and peripheral nerve interfaces. Recent developments have also witnessed the emergence of biodegradable and multifunctional devices. In this article, we aim to overview recent advances in implantable neuroelectronics with an emphasis on chronic biocompatibility, biodegradability, and multifunctionality. In addition to highlighting fundamental materials innovations, we also discuss important challenges and future opportunities.
材料创新在植入式神经电子学的发展中无疑发挥了最重要的作用之一。此类技术探索用于读取、触发和操纵神经信号的生物相容性工作系统，以用于神经科学研究，并为开发医疗诊断和/或治疗设备提供了额外的潜力。过去十年见证了神经电子材料研究的黄金时代。例如，基于软材料的设备的研发呈爆发式增长，并在包括中枢和外周神经接口在内的许多应用中占据了中心地位。最近的发展还见证了可生物降解和多功能设备的出现。在本文中，我们旨在概述植入式神经电子学的最新进展，重点关注长期生物相容性、生物可降解性和多功能性。除了突出基本的材料创新外，我们还讨论了重要的挑战和未来机遇。
