针对融合蛋白的单克隆抗体对坏死性流行性腮腺炎脑膜脑炎具有保护作用。
Monoclonal antibodies against the fusion protein are protective in necrotizing mumps meningoencephalitis.
作者信息
Löve A, Rydbeck R, Utter G, Orvell C, Kristensson K, Norrby E
出版信息
J Virol. 1986 Apr;58(1):220-2. doi: 10.1128/JVI.58.1.220-222.1986.
Abstract
A monoclonal antibody against the fusion (F) protein of mumps virus was found to confer marked protection in mumps virus-induced encephalitis. Almost total prevention of extensive brain necrosis was found. This study indicates that the virus F protein is directly involved in the pathogenesis of brain necrosis.
摘要
一种针对腮腺炎病毒融合（F）蛋白的单克隆抗体在腮腺炎病毒诱发的脑炎中显示出显著的保护作用。研究发现几乎完全预防了广泛的脑坏死。这项研究表明病毒F蛋白直接参与了脑坏死的发病机制。
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