Yoshida D, Matsumoto T, Okamoto H, Mizusaki S, Kushi A, Fukuhara Y
Environ Health Perspect. 1986 Aug;67:55-8. doi: 10.1289/ehp.866755.
We have demonstrated that the pyrolysis products of amino acids and proteins in model systems are mutagenic. The mutagenic principles in the pyrolyzates of amino acids have been isolated and identified by Sugimura et al. We have isolated and identified amino-alpha-carbolines from pyrolyzed soybean globulin as mutagens. The yield of mutagens by the heating of food constituents is changed by the heating method. Effects of heating methods on the yield of amino-alpha-carbolines were studied in a series of experiments, and the results are shown in this paper. Additionally, it has been shown that by the heating of creatine-sugar mixtures imidazoquinoline or quinoxaline mutagens are formed.
我们已经证明，在模型系统中氨基酸和蛋白质的热解产物具有致突变性。Sugimura等人已经分离并鉴定了氨基酸热解产物中的致突变成分。我们从热解大豆球蛋白中分离并鉴定出氨基-α-咔啉作为诱变剂。食品成分加热产生诱变剂的产量会因加热方法而改变。在一系列实验中研究了加热方法对氨基-α-咔啉产量的影响，结果在本文中呈现。此外，已经表明，通过加热肌酸-糖混合物会形成咪唑喹啉或喹喔啉诱变剂。
