Medical College of Nantong University, 19 QiXiu Road, Nantong City, Jiangsu Province, China.
Nantong North Rehabilitation Hospital, Nantong City, Jiangsu Province, China.
BMC Public Health. 2023 Aug 16;23(1):1555. doi: 10.1186/s12889-023-16494-x.
Many studies have revealed the effect of medical history on dementia. The aim of this study was to explore the relationship between the history of disease and onset of dementia.
This was a multi-center, cross-sectional study, with 2595 older adults enrolled. The onset of dementia was evaluated with Revised Hasegawa Dementia Scale (HDS-R). The diagnosed diseases after the age of 40 of the participants were investigated, including respiratory system diseases, digestive system diseases, cardiovascular diseases, endocrine disorders, genitourinary system diseases, nervous system disease, sensory system diseases, dental/oral diseases, bone/joint diseases and mental illnesses.
Data of 2458 older adults were analyzed. Univariate analysis showed that diabetes, thyroid disease, mental illness, hearing loss, stroke, dental/oral disease, Denture use, fracture/osteoporosis, kidney disease and number of diseases were risk factors for dementia. After controlling for demographic sociological variables, diabetes, dental/oral disease, and denture use were independent risk factors for dementia. Thyroid disease (P = 0.313), mental illnesses (P = 0.067), hearing loss (P = 0.595), stroke (P = 0.538), fractures/osteoporosis (P = 0.069), kidney disease (P = 0.168) were no longer significant to dementia.
Diabetes, dental/oral disease and denture use were main risk factors for dementia.
许多研究揭示了病史对痴呆的影响。本研究旨在探讨疾病史与痴呆发病之间的关系。
这是一项多中心、横断面研究，共纳入 2595 名老年人。采用修订后的 Hasegawa 痴呆量表（HDS-R）评估痴呆的发病情况。调查了参与者 40 岁以后的诊断疾病，包括呼吸系统疾病、消化系统疾病、心血管疾病、内分泌紊乱、泌尿生殖系统疾病、神经系统疾病、感觉系统疾病、牙科/口腔疾病、骨/关节疾病和精神疾病。
分析了 2458 名老年人的数据。单因素分析显示，糖尿病、甲状腺疾病、精神疾病、听力损失、中风、牙科/口腔疾病、义齿使用、骨折/骨质疏松症、肾脏疾病和疾病数量是痴呆的危险因素。在控制了人口社会学变量后，糖尿病、牙科/口腔疾病和义齿使用是痴呆的独立危险因素。甲状腺疾病（P=0.313）、精神疾病（P=0.067）、听力损失（P=0.595）、中风（P=0.538）、骨折/骨质疏松症（P=0.069）、肾脏疾病（P=0.168）与痴呆不再相关。
糖尿病、牙科/口腔疾病和义齿使用是痴呆的主要危险因素。
