Nichelli P, Bonito V, Candelise L, Capitani E, Manzoni S, Prencipe M, Sangiovanni G, Sinforiani E, Taiuti R, Fieschi C
Ital J Neurol Sci. 1986 Aug;7(4):443-6. doi: 10.1007/BF02283023.
A short neuropsychological test battery designed to measure language, memory and visuospatial abilities was administered to 217 patients with reversible ischemic attacks. Patients were tested twice: the first time more than one month, but less than one year, from the last ischemic episode, and the second time three years later. A comparison between the first and the second testing session did not disclose any significant worsening. The degree of atherosclerosis and the occurrence of further ischemic episodes during the follow-up period were found to be unrelated to change in performance at the test battery. These results seems to challenge the hypothesis that multi-infarct dementia may follow apparently reversible, or even clinically silent, ischemic episodes.
对217名可逆性缺血性发作患者进行了一项旨在测量语言、记忆和视觉空间能力的简短神经心理测试组。患者进行了两次测试：第一次是在距最后一次缺血发作一个多月但不到一年的时间，第二次是在三年后。第一次和第二次测试之间的比较未发现任何明显恶化。研究发现，随访期间的动脉粥样硬化程度和进一步缺血发作的发生与测试组表现的变化无关。这些结果似乎对多梗死性痴呆可能继发于明显可逆甚至临床无症状的缺血发作这一假设提出了挑战。
