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同一皮损中硬化萎缩性苔藓与硬斑病并存:一例报告

Coexistence of Lichen Sclerosus Et Atrophicus and Morphea in the Same Lesion: A Case Report.

作者信息

Siskou Styliani, Drongoula Ourania, Grammatikopoulou Julia, Nivatsi Paraskevi, Noukari Despina, Kokarida Aikaterini, Chrysoglou Charikleia Lydia, Chrysoglou Sofia-Ifigeneia, Vounotrypidis Periklis, Demirtzoglou Georgios, Goula Maria

机构信息

Department of Dermatology, State Hospital for Venereal and Skin Diseases, Thessaloniki, GRC.

Department of Plastic and Reconstructive Surgery, KAT Attica General Hospital, Athens, GRC.

出版信息

Cureus. 2023 Aug 7;15(8):e43062. doi: 10.7759/cureus.43062. eCollection 2023 Aug.

DOI:10.7759/cureus.43062
PMID:37680411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10481406/
Abstract

Lichen sclerosus et atrophicus (LSA) is an inflammatory dermatosis of unknown etiology, usually affecting the genital region, with extragenital involvement being uncommon. The coexistence of LSA and morphea in the same lesion is rare. The present study aims to demonstrate that LSA and morphea might share similar pathologic processes. We present a case of a 53-year-old female patient with extragenital lesions with clinical appearance and histopathological features of both LSA and morphea. Finally, the two diseases might lie on the same disease spectrum.

摘要

硬化萎缩性苔藓(LSA)是一种病因不明的炎症性皮肤病,通常累及生殖器部位,累及生殖器外部位的情况并不常见。LSA和硬斑病在同一病变中共存的情况很少见。本研究旨在证明LSA和硬斑病可能具有相似的病理过程。我们报告一例53岁女性患者,其生殖器外病变具有LSA和硬斑病的临床表现及组织病理学特征。最后,这两种疾病可能处于同一疾病谱上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10481406/888626bc4f6e/cureus-0015-00000043062-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10481406/a341cbe6a86c/cureus-0015-00000043062-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10481406/e0ec122755ef/cureus-0015-00000043062-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10481406/888626bc4f6e/cureus-0015-00000043062-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10481406/a341cbe6a86c/cureus-0015-00000043062-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10481406/e0ec122755ef/cureus-0015-00000043062-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223f/10481406/888626bc4f6e/cureus-0015-00000043062-i04.jpg

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Coexistence of Lichen Sclerosus and Morphea in a Single Vulvar Lesion.单发性外阴病变中硬化性苔藓与硬斑病并存。

本文引用的文献

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Front Med (Lausanne). 2023 Feb 16;10:1106318. doi: 10.3389/fmed.2023.1106318. eCollection 2023.
2
Morphea: The 2023 update.硬斑病:2023年更新版
Front Med (Lausanne). 2023 Feb 13;10:1108623. doi: 10.3389/fmed.2023.1108623. eCollection 2023.
3
Perifollicular Hypopigmentation in Systemic Sclerosis: Associations With Clinical Features and Internal Organ Involvement.系统性硬化症毛囊周围色素减退:与临床特征和内脏器官受累的关联。
Cureus. 2025 Jan 11;17(1):e77303. doi: 10.7759/cureus.77303. eCollection 2025 Jan.
J Rheumatol. 2022 May;49(5):475-481. doi: 10.3899/jrheum.210983. Epub 2022 Feb 15.
4
Histopathological Coexistence of Extragenital Lichen Sclerosus and Morphea in a Single Lesion.单个病灶中生殖器外硬化性苔藓和硬斑病的组织病理学共存
Cureus. 2020 Dec 22;12(12):e12215. doi: 10.7759/cureus.12215.
5
MicroRNA in localized scleroderma: a review of literature.局限性硬皮病中的 microRNA:文献综述。
Arch Dermatol Res. 2020 Jul;312(5):317-324. doi: 10.1007/s00403-019-01991-0. Epub 2019 Oct 21.
6
A potential contribution of decreased galectin-7 expression in stratified epithelia to the development of cutaneous and oesophageal manifestations in systemic sclerosis.层状上皮中半乳糖凝集素-7 表达减少可能有助于系统性硬皮病皮肤和食管表现的发生。
Exp Dermatol. 2019 May;28(5):536-542. doi: 10.1111/exd.13900.
7
Concomitant morphea and lichen sclerosus et atrophicus in the same plaque at the site of intramuscular drug injection: an interesting case presentation.肌肉注射部位同一斑块内同时出现硬斑病和萎缩性硬化性苔藓:一例有趣的病例报告。
Acta Dermatovenerol Alp Pannonica Adriat. 2018 Jun;27(2):111-113.
8
Lichen sclerosus et atrophicus.硬化萎缩性苔藓
Dermatol Online J. 2013 Dec 16;19(12):20714.
9
Coexistence of lichen sclerosus and morphea: a retrospective analysis of 472 patients with localized scleroderma from a German tertiary referral center.局限性硬皮病中硬化性苔藓和硬斑病共存:德国三级转诊中心 472 例局限性硬皮病患者的回顾性分析。
J Am Acad Dermatol. 2012 Dec;67(6):1157-62. doi: 10.1016/j.jaad.2012.04.003. Epub 2012 Apr 24.