Lederer Ann-Kathrin, Rasel Hannah, Kohnert Eva, Kreutz Clemens, Huber Roman, Badr Mohamed Tarek, Dellweg Patricia K E, Bartsch Fabian, Lang Hauke
Department of General, Visceral and Transplant Surgery, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
Center for Complementary Medicine, Department of Medicine II, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Microorganisms. 2023 Sep 21;11(9):2363. doi: 10.3390/microorganisms11092363.
Cancers of the biliary tract are more common in Asia than in Europe, but are highly lethal due to delayed diagnosis and aggressive tumor biology. Since the biliary tract is in direct contact with the gut via the enterohepatic circulation, this suggests a potential role of gut microbiota, but to date, the role of gut microbiota in biliary tract cancers has not been elucidated. This scoping review compiles recent data on the associations between the gut microbiota and diagnosis, progression and prognosis of biliary tract cancer patients. Systematic review of the literature yielded 154 results, of which 12 studies and one systematic review were eligible for evaluation. The analyses of microbiota diversity indices were inconsistent across the included studies. In-depth analyses revealed differences between gut microbiota of biliary tract cancer patients and healthy controls, but without a clear tendency towards particular species in the studies. Additionally, most of the studies showed methodological flaws, for example non-controlling of factors that affect gut microbiota. At the current stage, there is a lack of evidence to support a general utility of gut microbiota diagnostics in biliary tract cancers. Therefore, no recommendation can be made at this time to include gut microbiota analyses in the management of biliary tract cancer patients.
胆管癌在亚洲比在欧洲更为常见，但由于诊断延迟和肿瘤生物学行为侵袭性强，其致死率很高。由于胆道通过肠肝循环与肠道直接接触，这表明肠道微生物群可能发挥作用，但迄今为止，肠道微生物群在胆管癌中的作用尚未阐明。本综述汇编了关于肠道微生物群与胆管癌患者诊断、进展和预后之间关联的最新数据。对文献的系统综述产生了154个结果，其中12项研究和1项系统综述符合评估条件。纳入研究中微生物群多样性指数的分析结果不一致。深入分析揭示了胆管癌患者与健康对照者肠道微生物群之间的差异，但研究中没有明显倾向于特定物种。此外，大多数研究存在方法学缺陷，例如未控制影响肠道微生物群的因素。在现阶段，缺乏证据支持肠道微生物群诊断在胆管癌中的普遍应用。因此，目前无法建议将肠道微生物群分析纳入胆管癌患者的管理中。
