Burnett C M, Goldenthal E I
Food Chem Toxicol. 1986 Aug;24(8):819-23. doi: 10.1016/0278-6915(86)90071-2.
The teratogenic potential of D & C Yellow No. 8, sodium fluorescein (C.I. No. 45350, CAS No. 518-47-8) was determined in rats and rabbits. An aqueous solution of the dye was administered by gavage to groups of 25 Charles River Sprague-Dawley rats at doses of 100, 500 and 1500 mg/kg on days 6-19 of gestation and to groups of 14 Dutch Belted rabbits at doses of 30, 100 and 250 mg/kg on days 6-27 of gestation. These doses did not result in evidence of maternal toxicity or adverse effects on foetal development.
在大鼠和兔子身上测定了D&C黄8号（荧光素钠，C.I.编号45350，CAS编号518 - 47 - 8）的致畸潜力。在妊娠第6至19天，将该染料的水溶液经口灌胃给予25只Charles River Sprague - Dawley大鼠，剂量分别为100、500和1500毫克/千克；在妊娠第6至27天，将该染料的水溶液经口灌胃给予14只荷兰带兔，剂量分别为30、100和250毫克/千克。这些剂量未导致母体毒性或对胎儿发育产生不良影响的证据。
