Dickerson Josie, Bridges Sally, Willan Kathryn, Kelly Brian, Moss Rachael H, Lister Jennie, Netkitsing Chandani, Atkinson Amy L, Bird Philippa K, Uphoff Eleanora P, Mason Dan, Newsham Alex, Waiblinger Dagmar, Razaq Rifat, Ahern Sara, Bryant Maria, Blower Sarah L, Pickett Kate E, McEachan Rosemary M, Wright John
Born in Bradford, Bradford Teaching Hospitals National Health Service Foundation Trust, Bradford, BD9 6RJ, UK.
Health Sciences, University of York, York, YO10 5DD, UK.
Wellcome Open Res. 2023 Sep 21;7:244. doi: 10.12688/wellcomeopenres.18394.2. eCollection 2022.
The Born in Bradford's Better Start (BiBBS) interventional birth cohort study was designed as an innovative cohort platform for efficient evaluation of early life interventions delivered through the Better Start Bradford programme. There are a growing number of interventional cohorts being implemented internationally. This paper provides an interim analysis of BiBBS in order to share learning about the feasibility and value of this method. Recruitment began in January 2016 and will complete in December 2023 with a target sample of 5,000 pregnancies. An interim analysis was completed for all pregnancies recruited between January 2016 and November 2019 with an expected due date between 1 April 2016 and 8 March 2020. Descriptive statistics were completed on the data. Of 4,823 eligible pregnancies, 2,626 (54%) pregnancies were recruited, resulting in 2,392 mothers and 2,501 children. The sample are representative of the pregnant population (61% Pakistani heritage; 12% White British; 8% other South Asian and 6% Central and Eastern European ethnicity). The majority of participants (84%) live in the lowest decile of the Index of Multiple Deprivation, and many live in vulnerable circumstances. A high proportion (85%) of BiBBS families have engaged in one or more of the Better Start Bradford interventions. Levels of participation varied by the characteristics of the interventions, such as the requirement for active participation and the length of commitment to a programme. We have demonstrated the feasibility of recruiting an interventional cohort that includes seldom heard families from ethnic minority and deprived backgrounds. The high level of uptake of interventions is encouraging for the goal of evaluating the process and outcomes of multiple early life interventions using the innovative interventional cohort approach. BiBBS covers a period before, during and after the coronavirus disease 2019 (COVID-19) pandemic which adds scientific value to the cohort.
布拉德福德出生即更好开端（BiBBS）干预性出生队列研究被设计为一个创新的队列平台，用于高效评估通过布拉德福德更好开端计划实施的早期生活干预措施。国际上正在实施的干预性队列越来越多。本文对BiBBS进行中期分析，以便分享有关该方法的可行性和价值的经验。招募工作于2016年1月开始，将于2023年12月完成，目标样本为5000例妊娠。对2016年1月至2019年11月招募的所有预期预产期在2016年4月1日至2020年3月8日之间的妊娠进行了中期分析。对数据进行了描述性统计。在4823例符合条件的妊娠中，招募了2626例（54%）妊娠，产生了2392名母亲和2501名儿童。该样本代表了孕妇群体（61%为巴基斯坦裔；12%为英国白人；8%为其他南亚裔，6%为中欧和东欧裔）。大多数参与者（84%）生活在多重剥夺指数的最低十分位数，许多人生活在脆弱环境中。BiBBS家庭中有很大比例（85%）参与了一项或多项布拉德福德更好开端干预措施。参与程度因干预措施的特点而异，例如积极参与的要求和对一项计划的参与时长。我们已经证明了招募一个干预性队列的可行性，该队列包括来自少数族裔和贫困背景、鲜为人知的家庭。干预措施的高接受度对于使用创新的干预性队列方法评估多种早期生活干预措施的过程和结果的目标来说是令人鼓舞的。BiBBS涵盖了2019冠状病毒病（COVID-19）大流行之前、期间和之后的一段时间，这为该队列增加了科学价值。
