Nakamoto Atsushi, Onishi Hiromitsu, Tsuboyama Takahiro, Fukui Hideyuki, Ota Takashi, Yano Keigo, Kiso Kengo, Honda Toru, Tarewaki Hiroyuki, Koyama Yoshihiro, Tatsumi Mitsuaki, Tomiyama Noriyuki
Department of Future Diagnostic Radiology, Osaka University Graduate School of Medicine.
Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine.
Magn Reson Med Sci. 2025 Jan 1;24(1):58-65. doi: 10.2463/mrms.mp.2023-0039. Epub 2023 Oct 28.
To compare objective and subjective image quality, lesion conspicuity, and apparent diffusion coefficient (ADC) of high-resolution multiplexed sensitivity-encoding diffusion-weighted imaging (MUSE-DWI) with conventional DWI (c-DWI) and reduced FOV DWI (rFOV-DWI) in prostate MRI.
Forty-seven patients who underwent prostate MRI, including c-DWI, rFOV-DWI, and MUSE-DWI, were retrospectively evaluated. SNR and ADC of normal prostate tissue and contrast-to-noise ratio (CNR) and ADC of prostate cancer (PCa) were measured and compared between the three sequences. Image quality and lesion conspicuity were independently graded by two radiologists using a 5-point scale and compared between the three sequences.
The SNR of normal prostate tissue was significantly higher with rFOV-DWI than with the other two DWI techniques (P ≤ 0.01). The CNR of the PCa was significantly higher with rFOV-DWI than with MUSE-DWI (P < 0.05). The ADC of normal prostate tissue measured by rFOV-DWI was lower than that measured by MUSE-DWI and c-DWI (P < 0.01), while there was no difference in the ADC of cancers. In the qualitative analysis, MUSE-DWI showed significantly higher scores than rFOV-DWI and c-DWI for visibility of anatomy and overall image quality in both readers, and significantly higher scores for distortion in one of the two readers (P < 0.001). There was no difference in lesion conspicuity between the three sequences.
High-resolution MUSE-DWI showed higher image quality and reduced distortion compared to c-DWI, while maintaining a wide FOV and similar ADC quantification, although no difference in lesion conspicuity was observed.
比较高分辨率多重敏感性编码扩散加权成像（MUSE-DWI）与传统扩散加权成像（c-DWI）及减少视野扩散加权成像（rFOV-DWI）在前列腺MRI中的客观和主观图像质量、病变显示度及表观扩散系数（ADC）。
回顾性评估47例行前列腺MRI检查的患者，检查序列包括c-DWI、rFOV-DWI和MUSE-DWI。测量并比较三种序列中正常前列腺组织的信噪比（SNR）和ADC以及前列腺癌（PCa）的对比噪声比（CNR）和ADC。两名放射科医生使用5分制对图像质量和病变显示度进行独立评分，并比较三种序列之间的差异。
rFOV-DWI序列中正常前列腺组织的SNR显著高于其他两种DWI技术（P≤0.01）。rFOV-DWI序列中PCa的CNR显著高于MUSE-DWI（P<0.05）。rFOV-DWI测量的正常前列腺组织ADC低于MUSE-DWI和c-DWI（P<0.01），而癌症的ADC无差异。在定性分析中，两位读者均认为MUSE-DWI在解剖结构可见性和整体图像质量方面的得分显著高于rFOV-DWI和c-DWI，在其中一位读者中，MUSE-DWI在变形方面的得分也显著更高（P<0.001）。三种序列在病变显示度上无差异。
高分辨率MUSE-DWI与c-DWI相比，图像质量更高且变形减少，同时保持了较宽的视野和相似的ADC定量，尽管在病变显示度上未观察到差异。
