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安全性、有效性与恶意:审视2022年10月美国一个队列中新出现的未接种疫苗的可转变中间人群对新冠疫苗的认知

Safety, Efficacy, and Ill Intent: Examining COVID-19 Vaccine Perceptions among the New Undervaccinated Moveable Middle in a U.S. Cohort, October 2022.

作者信息

Piltch-Loeb Rachael, Penrose Kate, Stanton Eva, Parcesepe Angela M, Shen Yanhan, Fleary Sasha A, Nash Denis

机构信息

Department of Environmental Occupational and Geospatial Health Sciences, Graduate School of Public Health and Health Policy, City University of New York (CUNY), New York, NY 10027, USA.

Institute for Implementation Science in Population Health (ISPH), City University of New York (CUNY), New York, NY 10027, USA.

出版信息

Vaccines (Basel). 2023 Oct 31;11(11):1665. doi: 10.3390/vaccines11111665.

DOI:10.3390/vaccines11111665
PMID:38005997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10675675/
Abstract

Individuals who received their primary vaccine series only (with no subsequent booster) may be a new type of "moveable middle" given their receipt of the original COVID-19 vaccination. One population within the moveable middle for whom tailored interventions may be needed is individuals with common mental disorders (CMD). The purpose of this paper is to understand the vaccine perceptions among this new moveable middle-the undervaccinated-and within the undervaccinated to examine the extent to which COVID-19 vaccine perceptions and motivations differ among those with and without symptoms of CMD. Using data from the CHASING COVID Cohort, we examine the relationship between vaccination status, CMD, and vaccine perceptions in the undervaccinated. Among 510 undervaccinated participants who had completed the primary vaccine series but were not boosted, the most common reasons for undervaccination focused on efficacy (not seeing a need for an additional dose, 42.4%; there not being enough evidence that a booster dose is effective, 26.5%; already having had COVID-19, 19.6%). Other concerns were related to safety (long-term side effects, 21.0%; short-term side effects, 17.6%) and logistics (plan to get a booster but haven't had time yet, 18.8%). Overall, the greatest vaccine concerns (over 30%) for the undervaccinated focused on efficacy and safety issues. Symptoms of depression or anxiety were associated with lower levels of vaccine efficacy and greater safety concerns in adjusted models. The implications of our study are that campaigns that are hoping to maximize vaccination uptake should consider focusing on and emphasizing messaging on efficacy and safety issues.

摘要

仅接种了初级疫苗系列(未接种后续加强针)的个体,鉴于其接种了原始的新冠疫苗,可能成为一种新型的“可移动中间群体”。对于可移动中间群体中可能需要量身定制干预措施的一类人群,是患有常见精神障碍(CMD)的个体。本文的目的是了解这个新的可移动中间群体——未充分接种疫苗者——以及未充分接种疫苗者内部对疫苗的看法,以研究有和没有CMD症状的人群在新冠疫苗认知和接种动机方面的差异程度。利用来自“追踪新冠队列研究”的数据,我们研究了未充分接种疫苗者的疫苗接种状况、CMD和疫苗认知之间的关系。在510名完成了初级疫苗系列接种但未接种加强针的未充分接种疫苗参与者中,未充分接种疫苗的最常见原因集中在有效性方面(认为不需要额外一剂,42.4%;没有足够证据表明加强针有效,26.5%;已经感染过新冠,19.6%)。其他担忧与安全性(长期副作用,21.0%;短期副作用,17.6%)和后勤保障(计划接种加强针但还没时间,18.8%)有关。总体而言,未充分接种疫苗者最主要的疫苗担忧(超过30%)集中在有效性和安全性问题上。在调整后的模型中,抑郁或焦虑症状与较低的疫苗有效性认知水平以及更高的安全性担忧相关。我们研究的意义在于,希望最大限度提高疫苗接种率的宣传活动应考虑重点关注并强调关于有效性和安全性问题的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba40/10675675/245fa7ba45c5/vaccines-11-01665-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba40/10675675/f7d5d1dcb8d3/vaccines-11-01665-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba40/10675675/d4d81c478fa9/vaccines-11-01665-g0A2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba40/10675675/a0e90abc298f/vaccines-11-01665-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba40/10675675/245fa7ba45c5/vaccines-11-01665-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba40/10675675/f7d5d1dcb8d3/vaccines-11-01665-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba40/10675675/d4d81c478fa9/vaccines-11-01665-g0A2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba40/10675675/a0e90abc298f/vaccines-11-01665-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba40/10675675/245fa7ba45c5/vaccines-11-01665-g002.jpg

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