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自发性小鼠B细胞白血病（BCL1）的特征。II. 脂多糖刺激后肿瘤细胞的增殖和IgM分泌

Characterization of a spontaneous murine B cell leukemia (BCL1). II. Tumor cell proliferation and IgM secretion after stimulation by LPS.

作者信息

Knapp M R, Severinson-Gronowicz E, Schröder J, Strober S

出版信息

J Immunol. 1979 Sep;123(3):1000-6.

PMID:381513
Abstract

A spontaneous BALB/c B lymphocyte leukemia could be stimulated in vitro by the polyclonal B cell activator lipopolysaccharide (LPS) and the conditions for activation were studied. Spleen cells or peripheral blood lymphocytes from tumor-bearing animals responded by increased DNA synthesis and the peak of activation occurred earlier than with normal mouse spleen cells. Tumor cells harvested from the spleen, but not from the peripheral blood, could be induced by LPS to secrete IgM. Direct demonstration that the response was due to tumor cell activation and not that of contaminating normal B lymphocytes was provided by karyotype analysis and by immunoprecipitation, which showed the restriction of light chains on secreted IgM molecules to the lambda isotype.

摘要

一种自发的BALB/c B淋巴细胞白血病可在体外被多克隆B细胞激活剂脂多糖（LPS）刺激，并对激活条件进行了研究。荷瘤动物的脾细胞或外周血淋巴细胞通过增加DNA合成做出反应，且激活峰值比正常小鼠脾细胞出现得更早。从脾脏而非外周血中收获的肿瘤细胞可被LPS诱导分泌IgM。核型分析和免疫沉淀直接证明了该反应是由于肿瘤细胞激活而非污染的正常B淋巴细胞激活所致，免疫沉淀显示分泌的IgM分子上的轻链限于λ同种型。

相似文献

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Characterization of a spontaneous murine B cell leukemia (BCL1). II. Tumor cell proliferation and IgM secretion after stimulation by LPS.自发性小鼠B细胞白血病（BCL1）的特征。II. 脂多糖刺激后肿瘤细胞的增殖和IgM分泌
J Immunol. 1979 Sep;123(3):1000-6.
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引用本文的文献

1
Acquisition of cell surface IgD after in vitro culture of neoplastic B cells from the murine tumor BCL1.对来自小鼠肿瘤BCL1的肿瘤性B细胞进行体外培养后获得细胞表面IgD。
J Exp Med. 1980 Mar 1;151(3):749-54. doi: 10.1084/jem.151.3.749.
2
Production of a B cell growth-promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor.从一个克隆的T细胞系产生B细胞生长促进活性物质（DL）BCGF及其对BCL1 B细胞肿瘤的检测
J Exp Med. 1982 Dec 1;156(6):1821-34. doi: 10.1084/jem.156.6.1821.
3
Mediators from cloned T helper cell lines affect immunoglobulin expression by B cells.
来自克隆的辅助性T细胞系的介质影响B细胞的免疫球蛋白表达。
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4756-60. doi: 10.1073/pnas.79.15.4756.
4
Simultaneous expression of immunoglobulin mu and delta heavy chains by a cloned B-cell lymphoma: a single copy of the VH gene is shared by two adjacent CH genes.一个克隆的B细胞淋巴瘤同时表达免疫球蛋白μ链和δ重链：两个相邻的CH基因共享一个VH基因单拷贝。
Proc Natl Acad Sci U S A. 1982 May;79(9):2996-3000. doi: 10.1073/pnas.79.9.2996.
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Induction of proliferation and differentiation of neoplastic B cells by anti-immunoglobulin and T-cell factors.抗免疫球蛋白和T细胞因子诱导肿瘤性B细胞的增殖与分化
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2507-11. doi: 10.1073/pnas.78.4.2507.
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Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays.在不同功能检测中具有活性的两类不同小鼠B细胞生长因子的证据。
J Exp Med. 1983 Sep 1;158(3):822-35. doi: 10.1084/jem.158.3.822.
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Immunoglobulin gene expression in transformed lymphoid cells.转化淋巴细胞中的免疫球蛋白基因表达。
Proc Natl Acad Sci U S A. 1983 Feb;80(3):825-9. doi: 10.1073/pnas.80.3.825.
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Transcriptional regulation of the mu-delta heavy chain locus in normal murine B lymphocytes.正常小鼠B淋巴细胞中μ-δ重链基因座的转录调控。
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