吸入的2-丁氧基乙醇（乙二醇单丁醚）在人体中的毒代动力学。

Toxicokinetics of inhaled 2-butoxyethanol (ethylene glycol monobutyl ether) in man.

作者信息

Johanson G, Kronborg H, Näslund P H, Byfält Nordqvist M

出版信息

Scand J Work Environ Health. 1986 Dec;12(6):594-602. doi: 10.5271/sjweh.2097.

DOI:10.5271/sjweh.2097

Abstract

Seven male volunteers were exposed to 2-butoxyethanol at the Swedish occupational exposure limit (20 ppm or 0.85 mmol/m3) during light physical exercise (50 W) on a bicycle ergometer. The exposure took place in an exposure chamber and lasted 2 h. Expired air was collected at regular time intervals for estimation of the respiratory uptake of the solvent. Arterialized capillary blood and urine were sampled during and after the exposure period and analyzed for 2-butoxyethanol and its metabolite butoxyacetic acid. A new sensitive method for analyzing 2-butoxyethanol in biological specimens is described. 2-Butoxyethanol was derivatized with pentafluorobenzoyl chloride and analyzed by gas chromatography with electron capture detection. The respiratory uptake of 2-butoxyethanol averaged 10.1 mumol/min or 57% of the inspired amount. The concentration in blood reached a plateau level of 7.4 mumol/l. The apparent values of elimination half-time, mean residence time, total blood clearance, and steady-state volume of distribution were 40 min, 42 min, 1.2 1/min and 54 l, respectively. The amount of 2-butoxyethanol excreted in urine was less than 0.03% of the total uptake, while that of butoxyacetic acid ranged from 17 to 55%.

摘要

七名男性志愿者在自行车测力计上进行轻度体育锻炼（50瓦）时，按照瑞典职业接触限值（20 ppm或0.85 mmol/m³）接触2-丁氧基乙醇。接触在暴露室内进行，持续2小时。定期收集呼出气体以估算溶剂的呼吸道摄入量。在接触期间和接触后采集动脉化毛细血管血和尿液样本，分析其中的2-丁氧基乙醇及其代谢产物丁氧基乙酸。描述了一种用于分析生物样本中2-丁氧基乙醇的新的灵敏方法。2-丁氧基乙醇用五氟苯甲酰氯衍生化，并用电子捕获检测气相色谱法进行分析。2-丁氧基乙醇的呼吸道摄入量平均为10.1 μmol/分钟，占吸入量的57%。血液中的浓度达到7.4 μmol/l的平台水平。消除半衰期、平均驻留时间、总血清除率和稳态分布容积的表观值分别为40分钟、42分钟、1.2 l/分钟和54升。尿液中排出的2-丁氧基乙醇量不到总摄入量的0.03%，而丁氧基乙酸的排出量在17%至55%之间。