Ma Jiaxin, Ding Linyu, Peng Xuqi, Jiang Lai, Liu Gang
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, 361102, China.
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
Small. 2024 Jul;20(28):e2308646. doi: 10.1002/smll.202308646. Epub 2024 Feb 9.
An immune reaction known as inflammation serves as a shield from external danger signals, but an overactive immune system may additionally lead to tissue damage and even a variety of inflammatory disorders. By inheriting biological functionalities and serving as both a therapeutic medication and a drug carrier, cell membrane-based nanotherapeutics offer the potential to treat inflammatory disorders. To further strengthen the anti-inflammatory benefits of natural cell membranes, researchers alter and optimize the membranes using engineering methods. This review focuses on engineered cell membrane-based nanotherapeutics (ECMNs) and their application in treating inflammation-related diseases. Specifically, this article discusses the methods of engineering cell membranes for inflammatory diseases and examines the progress of ECMNs in inflammation-targeted therapy, inflammation-neutralizing therapy, and inflammation-immunomodulatory therapy. Additionally, the article looks into the perspectives and challenges of ECMNs in inflammatory treatment and offers suggestions as well as guidance to encourage further investigations and implementations in this area.
一种被称为炎症的免疫反应是抵御外部危险信号的屏障，但免疫系统过度活跃可能会额外导致组织损伤，甚至引发各种炎症性疾病。基于细胞膜的纳米疗法继承了生物功能，既作为治疗药物又作为药物载体，为治疗炎症性疾病提供了潜力。为了进一步增强天然细胞膜的抗炎益处，研究人员采用工程方法对细胞膜进行改造和优化。本综述聚焦于基于工程化细胞膜的纳米疗法（ECMNs）及其在治疗炎症相关疾病中的应用。具体而言，本文讨论了针对炎症性疾病改造细胞膜的方法，并考察了ECMNs在炎症靶向治疗、炎症中和治疗以及炎症免疫调节治疗方面的进展。此外，本文探讨了ECMNs在炎症治疗中的前景与挑战，并提供建议及指导，以鼓励在该领域进行进一步的研究和应用。
