Seitz-Holland Johanna, Haas Shalaila S, Penzel Nora, Reichenberg Abraham, Pasternak Ofer
Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neurosci Biobehav Rev. 2024 Apr;159:105581. doi: 10.1016/j.neubiorev.2024.105581. Epub 2024 Feb 13.
The imaging-based method of brainAGE aims to characterize an individual's vulnerability to age-related brain changes. The present study systematically reviewed brainAGE findings in neuropsychiatric conditions and discussed the potential of brainAGE as a marker for biological age. A systematic PubMed search (from inception to March 6th, 2023) identified 273 articles. The 30 included studies compared brainAGE between neuropsychiatric and healthy groups (n≥50). We presented results qualitatively and adapted a bias risk assessment questionnaire. The imaging modalities, design, and input features varied considerably between studies. While the studies found higher brainAGE in neuropsychiatric conditions (11 mild cognitive impairment/ dementia, 11 schizophrenia spectrum/ other psychotic and bipolar disorder, six depression/ anxiety, two multiple groups), the associations with clinical characteristics were mixed. While brainAGE is sensitive to group differences, limitations include the lack of diverse training samples, multi-modal studies, and external validation. Only a few studies obtained longitudinal data, and all have used algorithms built solely to predict chronological age. These limitations impede the validity of brainAGE as a biological age marker.
基于成像的脑龄（brainAGE）方法旨在描述个体对与年龄相关的脑部变化的易感性。本研究系统回顾了神经精神疾病中的脑龄研究结果，并讨论了脑龄作为生物学年龄标志物的潜力。一项在PubMed上进行的系统检索（从数据库建立至2023年3月6日）共识别出273篇文章。纳入的30项研究比较了神经精神疾病组与健康组（n≥50）之间的脑龄。我们对结果进行了定性分析，并采用了偏倚风险评估问卷。各研究之间的成像方式、设计和输入特征差异很大。虽然这些研究发现神经精神疾病患者的脑龄较高（11项针对轻度认知障碍/痴呆，11项针对精神分裂症谱系/其他精神病性和双相情感障碍，6项针对抑郁/焦虑，2项针对多个组），但与临床特征的关联却各不相同。虽然脑龄对组间差异敏感，但其局限性包括缺乏多样的训练样本、多模态研究以及外部验证。只有少数研究获得了纵向数据，而且所有研究都使用了专门为预测实足年龄而构建的算法。这些局限性阻碍了脑龄作为生物学年龄标志物的有效性。
