使用“类器官群落”的细胞类型-表型关联
Cellotype-phenotype associations using 'organoid villages'.
作者信息
Kimura Masaki, Takebe Takanori
机构信息
Center for Stem Cell and Organoid Medicine (CuSTOM), Division of Gastroenterology, Hepatology and Nutrition, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Center for Stem Cell and Organoid Medicine (CuSTOM), Division of Gastroenterology, Hepatology and Nutrition, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan; Institute of Research, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan.
出版信息
Trends Endocrinol Metab. 2024 Jun;35(6):462-465. doi: 10.1016/j.tem.2024.03.001. Epub 2024 Apr 3.
En masse phenotyping technology, using massively mosaic donor-derived cells and organoids, can offer enriched insights for cellotype-phenotype association in a cell-type-specific regulatory context. This emerging approach will help to discover biomarkers, inform genetic-epigenetic interactions and identify personalized therapeutic targets, offering hope for precision medicine against highly heterogeneous metabolic diseases.
整体表型分析技术，利用大量嵌合的供体来源细胞和类器官，能够在细胞类型特异性调控背景下为细胞类型与表型的关联提供丰富的见解。这种新兴方法将有助于发现生物标志物、揭示遗传与表观遗传的相互作用并识别个性化治疗靶点，为针对高度异质性代谢疾病的精准医学带来希望。
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