College of Biology and Food Engineering, Chongqing Three Gorges University, Wanzhou, 404100, China.
College of Plant Protection, Shenyang Agricultural University, Shenyang, 110866, China.
Plant Mol Biol. 2024 May 7;114(3):53. doi: 10.1007/s11103-024-01417-0.
Plants have a variety of regulatory mechanisms to perceive, transduce, and respond to biotic and abiotic stress. One such mechanism is the calcium-sensing CBL-CIPK system responsible for the sensing of specific stressors, such as drought or pathogens. CBLs perceive and bind Calcium (Ca) in response to stress and then interact with CIPKs to form an activated complex. This leads to the phosphorylation of downstream targets, including transporters and ion channels, and modulates transcription factor levels and the consequent levels of stress-associated genes. This review describes the mechanisms underlying the response of the CBL-CIPK pathway to biotic and abiotic stresses, including regulating ion transport channels, coordinating plant hormone signal transduction, and pathways related to ROS signaling. Investigation of the function of the CBL-CIPK pathway is important for understanding plant stress tolerance and provides a promising avenue for molecular breeding.
植物具有多种调节机制来感知、转导和响应生物和非生物胁迫。其中一种机制是钙感应 CBL-CIPK 系统，负责感知特定的胁迫因子，如干旱或病原体。CBL 感知并结合钙以响应胁迫，然后与 CIPK 相互作用形成激活复合物。这导致下游靶标（包括转运体和离子通道）的磷酸化，调节转录因子水平和随后的应激相关基因水平。本综述描述了 CBL-CIPK 途径对生物和非生物胁迫响应的机制，包括调节离子转运通道、协调植物激素信号转导以及与 ROS 信号相关的途径。研究 CBL-CIPK 途径的功能对于理解植物的应激耐受性很重要，并为分子育种提供了一个有前途的途径。
