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鼠李斯特菌病肉芽肿内L3T4和Ly 2表型T细胞的动态变化

Dynamics of T cells of L3T4 and Ly 2 phenotype within granulomas in murine listeriosis.

作者信息

Näher H, Sperling U, Takacs L, Hahn H

出版信息

Clin Exp Immunol. 1985 Jun;60(3):559-64.

PMID:3874730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1577196/
Abstract

Monoclonal antibodies anti-Ly 1, anti-Ly 2 and GK1.5 were applied to determine phenotypes of T cells within granulomas formed as a result of infection of mice with the facultative intracellular bacterium Listeria monocytogenes. Early in granuloma formation, equal numbers of Ly 1+, Ly 2+ and L3T4+ cells were found, T cells of different phenotypes being evenly distributed over the lesions. In mature granulomas, numbers of Ly 1+ and L3T4+ cells about doubled as compared to incipient granulomas, Ly 2+ cells, however, remained constant. Whereas Ly 1+ and L3T4+ cells within mature granulomas still were evenly distributed, Ly 2+ cells were predominantly localized in the periphery of the lesions. The data indicate that both, specific Ly 2+ and L3T4+ T cells, display characteristic dynamics within granulomas: Ly 2+ T cells which most likely mature from Ly 1+2+ T cells over time locate to the periphery. Concomitantly, L3T4+ T cells are enriched maintaining their distribution all over the lesions.

摘要

应用抗Ly 1、抗Ly 2单克隆抗体和GK1.5来确定因兼性细胞内细菌单核细胞增生李斯特菌感染小鼠而形成的肉芽肿内T细胞的表型。在肉芽肿形成早期，发现Ly 1 +、Ly 2 +和L3T4 +细胞数量相等，不同表型的T细胞均匀分布于病变部位。在成熟肉芽肿中，Ly 1 +和L3T4 +细胞数量与初期肉芽肿相比约增加了一倍，然而，Ly 2 +细胞数量保持不变。成熟肉芽肿内的Ly 1 +和L3T4 +细胞仍均匀分布，而Ly 2 +细胞主要位于病变外周。数据表明，特异性Ly 2 +和L3T4 + T细胞在肉芽肿内均呈现出特征性动态变化：随着时间推移，最有可能从Ly 1 + 2 + T细胞成熟而来的Ly 2 + T细胞定位于外周。与此同时，L3T4 + T细胞数量增加并保持在病变部位均匀分布。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ebf/1577196/dab8cc8bc983/clinexpimmunol00135-0115-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ebf/1577196/dab8cc8bc983/clinexpimmunol00135-0115-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ebf/1577196/dab8cc8bc983/clinexpimmunol00135-0115-a.jpg

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Generation of effector cells from T cell subsets. III. Synergy between Lyt-1 and Lyt-123/23 lymphocytes in the generation of H-2-restricted and alloreactive cytotoxic T cell.从T细胞亚群产生效应细胞。III. Lyt-1和Lyt-123/23淋巴细胞在产生H-2限制性和同种异体反应性细胞毒性T细胞中的协同作用。
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T-cell subsets in delayed-type hypersensitivity, protection, and granuloma formation in primary and secondary Listeria infection in mice: superior role of Lyt-2+ cells in acquired immunity.小鼠原发性和继发性李斯特菌感染中迟发型超敏反应、保护性免疫及肉芽肿形成过程中的T细胞亚群：Lyt-2⁺细胞在获得性免疫中的优势作用
Infect Immun. 1988 Aug;56(8):1920-5. doi: 10.1128/iai.56.8.1920-1925.1988.
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Administration of purified anti-L3T4 monoclonal antibody impairs the resistance of mice to Listeria monocytogenes infection.给予纯化的抗L3T4单克隆抗体可削弱小鼠对单核细胞增生李斯特菌感染的抵抗力。
Infect Immun. 1989 Jan;57(1):100-9. doi: 10.1128/iai.57.1.100-109.1989.
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