Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271017, China.
Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Tai'an 271017, China.
Int J Mol Sci. 2024 May 31;25(11):6095. doi: 10.3390/ijms25116095.
Skeletal muscle grows in response to a combination of genetic and environmental factors, and its growth and development influence the quality of pork. Elucidating the molecular mechanisms regulating the growth and development of skeletal muscle is of great significance to both animal husbandry and farm management. The is an excellent pig breed based on the original , importing the genes of the for meat traits, and cultivated through years of scientific selection and breeding. In this study, full-length transcriptome sequencing was performed on three growth stages of , aiming to study the developmental changes in at different developmental stages at the molecular level and to screen the key genes affecting the growth of skeletal muscle in . We performed an enrichment analysis of genes showing differential expression and constructed a protein-protein interaction network with the aim of identifying core genes involved in the development of . Notably, genes such as , , , and may be potential regulators of muscle development in . Our results contribute to the understanding of the molecular mechanisms of skeletal muscle development in this pig breed, which will facilitate molecular breeding efforts and the development of pig breeds to meet the needs of the livestock industry.
骨骼肌的生长是遗传和环境因素共同作用的结果，其生长发育影响猪肉的品质。阐明调控骨骼肌生长发育的分子机制，对畜牧业和农场管理具有重要意义。是一个优秀的猪种，它基于原始的品种，导入了的基因用于肉质特征，并通过多年的科学选择和繁殖进行培育。在这项研究中，对三个生长阶段的进行了全长转录组测序，旨在从分子水平上研究不同发育阶段骨骼肌的发育变化，并筛选影响骨骼肌生长的关键基因。我们对差异表达的基因进行了富集分析，并构建了一个蛋白质-蛋白质相互作用网络，旨在鉴定参与发育的核心基因。值得注意的是，、、、和等基因可能是该品种肌肉发育的潜在调节因子。我们的研究结果有助于理解该猪种骨骼肌发育的分子机制，这将有助于分子育种工作和猪种的发展，以满足畜牧业的需求。
