Schønheyder H, Andersen P, Petersen J C
Eur J Clin Microbiol. 1985 Jun;4(3):299-303. doi: 10.1007/BF02013657.
A rapid immunoelectrophoretic assay was developed to detect antibodies to Aspergillus fumigatus catalase. The method's diagnostic sensitivity for pulmonary aspergillosis was 88% (72-97%, 95% confidence limits) in 33 patients presenting with either aspergilloma or Aspergillus lung infiltrate. The diagnostic specificity was 94% (90-97%) as judged from 191 patients with other infiltrative lung diseases, including infections and neoplasia. None of the 185 healthy subjects had catalase antibodies. The highest titres (ranging up to 256) were found in aspergillosis patients with cavitary lesions. Catalase antibody titres increased in two patients with concomitant development of lung cavities and mycetomas. In patients with resected or stable Aspergillus lung disorders catalase antibody titres declined by less than one dilution step per year.
开发了一种快速免疫电泳测定法来检测烟曲霉过氧化氢酶抗体。在33例患有曲菌球或曲霉菌肺部浸润的患者中，该方法对肺曲霉病的诊断敏感性为88%（72 - 97%，95%置信区间）。从191例患有其他浸润性肺部疾病（包括感染和肿瘤）的患者判断，诊断特异性为94%（90 - 97%）。185名健康受试者均无过氧化氢酶抗体。在有空洞性病变的曲霉病患者中发现了最高滴度（高达256）。两名同时出现肺空洞和真菌瘤的患者过氧化氢酶抗体滴度升高。在切除或病情稳定的曲霉菌肺部疾病患者中，过氧化氢酶抗体滴度每年下降不到一个稀释度。
