Schønheyder H, Jensen T, Laessøe I H, Høiby N, Koch C
Institute of Medical Microbiology, University of Aarhus, Denmark.
Eur J Clin Microbiol Infect Dis. 1988 Feb;7(1):40-4. doi: 10.1007/BF01962169.
Seven to ten percent of patients with cystic fibrosis had serum antibodies to the catalase antigen of Aspergillus fumigatus in three cross-sectional surveys between 1977 and 1984. A total of 208 patients participated at least once, and the cumulated frequency of catalase antibodies in 94 patients included in all three surveys was 16%. The titre range was 1 to 16. The prevalence rate of Aspergillus fumigatus in sputum was 50% for a 2.5-year observation period. Catalase antibodies were strongly associated with the occurrence of Aspergillus fumigatus in sputum (p = 0.003), and the microorganism was more numerous in colonized patients with catalase antibodies than in those without such antibodies (p = 0.004). Patients with Aspergillus fumigatus in sputum and a positive catalase antibody test tended to have an adverse development as regards lung function compared to both carriers without antibodies and non-carriers. The observed differences could not, however, be related to different rates of chronic Pseudomonas aeruginosa infection.
在1977年至1984年间的三项横断面调查中，7%至10%的囊性纤维化患者血清中含有针对烟曲霉过氧化氢酶抗原的抗体。共有208名患者至少参与了一次调查，在所有三项调查中的94名患者中，过氧化氢酶抗体的累积频率为16%。滴度范围为1至16。在2.5年的观察期内，痰液中烟曲霉的患病率为50%。过氧化氢酶抗体与痰液中烟曲霉的出现密切相关（p = 0.003），与没有此类抗体的定植患者相比，有过氧化氢酶抗体的定植患者体内的微生物数量更多（p = 0.004）。与无抗体携带者和非携带者相比，痰液中有烟曲霉且过氧化氢酶抗体检测呈阳性的患者在肺功能方面往往有不良进展。然而，观察到的差异与慢性铜绿假单胞菌感染率的不同无关。
