山竹果皮多糖及其衍生物的抗氧化活性。
Antioxidant activity of polysaccharide from Garcinia mangostana rind and their derivatives.
机构信息
Key Laboratory of Carbohydrate Science and Engineering, Chongqing Normal University, Chongqing, 401331, China.
出版信息
BMC Complement Med Ther. 2024 Jul 25;24(1):283. doi: 10.1186/s12906-024-04594-z.
BACKGROUND
Polysaccharide from Garcinia mangostana rind has many biological activities and deserves further research.
METHODS
The antioxidant properties of UAEE-GMRP, UAEE-GMRP-1 A, CM-30, and Ac-30 were evaluated through two different antioxidant activity experimental systems.
RESULTS
The four polysaccharides had a better scavenging effect on hydroxyl radicals, while their inhibitory effect on lipid peroxidation was relatively weak. However, overall, the four polysaccharides showed a certain degree of potential application in the two antioxidant experiments mentioned above, especially the chemically modified polysaccharides from Garcinia mangostana rind, which effectively improved their antioxidant activity. This also indicates that chemical modification is a better method to improve polysaccharide activity. In addition, in these two antioxidant exploration experiments, carboxymethylated polysaccharide showed stronger activity compared to the other three polysaccharides.
CONCLUSION
The carboxymethylation modification may have great potential for application.
背景
藤黄果皮多糖具有多种生物活性，值得进一步研究。
方法
采用两种不同的抗氧化活性实验体系，评价 UAEE-GMRP、UAEE-GMRP-1A、CM-30 和 Ac-30 的抗氧化性能。
结果
四种多糖对羟基自由基均具有较好的清除作用，而对脂质过氧化的抑制作用相对较弱。然而，总体而言，四种多糖在上述两种抗氧化实验中均表现出一定的潜在应用价值，特别是化学修饰的藤黄果皮多糖，有效提高了其抗氧化活性。这也表明化学修饰是提高多糖活性的一种较好方法。此外，在这两种抗氧化探索实验中，羧甲基化多糖的活性均强于其他三种多糖。
结论
羧甲基化修饰可能具有很大的应用潜力。
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