Taghdi Manal Hussein, Muttiah Barathan, Chan Alvin Man Lung, Fauzi Mh Busra, Law Jia Xian, Lokanathan Yogeswaran
Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Department of Anaesthesia and Intensive Care, Faculty of Medical Technology, University of Tripoli, Tripoli P.O. Box 13932, Libya.
Biomedicines. 2024 Jul 18;12(7):1605. doi: 10.3390/biomedicines12071605.
Regenerative medicine represents a paradigm shift in healthcare, aiming to restore tissue and organ function through innovative therapeutic strategies. Among these, bioprinting and extracellular vesicles (EVs) have emerged as promising techniques for tissue rejuvenation. EVs are small lipid membrane particles secreted by cells, known for their role as potent mediators of intercellular communication through the exchange of proteins, genetic material, and other biological components. The integration of 3D bioprinting technology with EVs offers a novel approach to tissue engineering, enabling the precise deposition of EV-loaded bioinks to construct complex three-dimensional (3D) tissue architectures. Unlike traditional cell-based approaches, bioprinted EVs eliminate the need for live cells, thereby mitigating regulatory and financial obstacles associated with cell therapy. By leveraging the synergistic effects of EVs and bioprinting, researchers aim to enhance the therapeutic outcomes of skin regeneration while addressing current limitations in conventional treatments. This review explores the evolving landscape of bioprinted EVs as a transformative approach for skin regeneration. Furthermore, it discusses the challenges and future directions in harnessing this innovative therapy for clinical applications, emphasizing the need for interdisciplinary collaboration and continued scientific inquiry to unlock its full therapeutic potential.
再生医学代表了医疗保健领域的范式转变，旨在通过创新的治疗策略恢复组织和器官功能。其中，生物打印和细胞外囊泡（EVs）已成为组织年轻化的有前景的技术。EVs是细胞分泌的小脂质膜颗粒，因其通过蛋白质、遗传物质和其他生物成分的交换作为细胞间通讯的有效介质而闻名。3D生物打印技术与EVs的整合为组织工程提供了一种新方法，能够精确沉积负载EV的生物墨水以构建复杂的三维（3D）组织结构。与传统的基于细胞的方法不同，生物打印的EVs无需活细胞，从而减轻了与细胞治疗相关的监管和财务障碍。通过利用EVs和生物打印的协同效应，研究人员旨在提高皮肤再生的治疗效果，同时解决传统治疗方法目前存在的局限性。本综述探讨了生物打印的EVs作为皮肤再生变革性方法的发展前景。此外，它还讨论了将这种创新疗法应用于临床的挑战和未来方向，强调了跨学科合作和持续科学探究以释放其全部治疗潜力的必要性。
