State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ministry of Agriculture and Rural Affairs Key Laboratory of Vegetable Legumes Germplasm Enhancement and Molecular Breeding in Southern China, Zhejiang Xianghu Laboratory, Institute of Vegetables, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Nat Genet. 2024 Sep;56(9):1964-1974. doi: 10.1038/s41588-024-01867-8. Epub 2024 Aug 5.
Peas are essential for human nutrition and played a crucial role in the discovery of Mendelian laws of inheritance. In this study, we assembled the genome of the elite vegetable pea cultivar 'Zhewan No. 1' at the chromosome level and analyzed resequencing data from 314 accessions, creating a comprehensive map of genetic variation in peas. We identified 235 candidate loci associated with 57 important agronomic traits through genome-wide association studies. Notably, we pinpointed the causal gene haplotypes responsible for four Mendelian traits: stem length (Le/le), flower color (A/a), cotyledon color (I/i) and seed shape (R/r). Additionally, we discovered the genes controlling pod form (Mendelian P/p) and hilum color. Our study also involved constructing a gene expression atlas across 22 tissues, highlighting key gene modules related to pod and seed development. These findings provide valuable pea genomic information and will facilitate the future genome-informed improvement of pea crops.
豌豆是人类营养的必需品，在孟德尔遗传定律的发现中发挥了关键作用。在这项研究中，我们以染色体水平组装了优良蔬菜豌豆品种‘浙豌 1 号’的基因组，并对来自 314 个品系的重测序数据进行了分析，创建了豌豆遗传变异的综合图谱。通过全基因组关联研究，我们鉴定了 235 个与 57 个重要农艺性状相关的候选基因座。值得注意的是，我们定位了导致四个孟德尔性状的因果基因单倍型：茎长（Le/le）、花色（A/a）、子叶颜色（I/i）和种子形状（R/r）。此外，我们还发现了控制荚形（孟德尔 P/p）和种脐颜色的基因。我们的研究还包括构建了 22 种组织的基因表达图谱，突出了与荚和种子发育相关的关键基因模块。这些发现提供了有价值的豌豆基因组信息，将有助于未来利用基因组信息对豌豆作物进行改良。
