Department of Chemistry, Inha University, Incheon 22212, Republic of Korea.
Nanoscale. 2024 Sep 12;16(35):16313-16328. doi: 10.1039/d4nr02059f.
Carbon materials and their hybrid metal composites have garnered significant attention in biomedical applications due to their exceptional biocompatibility. This biocompatibility arises from their inherent chemical stability and low toxicity within biological systems. This review offers a comprehensive overview of carbon nanomaterials and their metal composites, emphasizing their biocompatibility-focused applications, including drug delivery, bioimaging, biosensing, and tissue engineering. The paper outlines advancements in surface modifications, coatings, and functionalization techniques designed to enhance the biocompatibility of carbon materials, ensuring minimal adverse effects in biological systems. A comprehensive investigation into hybrid composites integrating carbon nanomaterials is conducted, categorizing them as fullerenes, carbon quantum dots, carbon nanotubes, carbon nanofibers, graphene, and diamond-like carbon. The concluding section addresses regulatory considerations and challenges associated with integrating carbon materials into medical devices. This review culminates by providing insights into current achievements, challenges, and future directions, underscoring the pivotal role of carbon nanomaterials and their metal composites in advancing biocompatible applications.
碳材料及其杂化金属复合材料由于其出色的生物相容性，在生物医学应用中受到了极大关注。这种生物相容性源于它们在生物体系内固有的化学稳定性和低毒性。本综述全面介绍了碳纳米材料及其金属复合材料，重点介绍了它们在药物输送、生物成像、生物传感和组织工程等以生物相容性为重点的应用。本文概述了旨在提高碳材料生物相容性的表面改性、涂层和功能化技术的进展，以确保在生物体系中产生最小的不良反应。对整合了碳纳米材料的杂化复合材料进行了全面的研究，将其分类为富勒烯、碳量子点、碳纳米管、碳纳米纤维、石墨烯和类金刚石碳。结论部分讨论了与将碳材料整合到医疗器械相关的监管考虑因素和挑战。本综述最后提供了对当前成就、挑战和未来方向的见解，强调了碳纳米材料及其金属复合材料在推进生物相容应用方面的关键作用。
