Nakama K, Shichinohe K, Kobayashi K, Naito K, Uchida O, Yasuhara K, Tobe M
Acta Diabetol Lat. 1985 Oct-Dec;22(4):335-42. doi: 10.1007/BF02624752.
Spontaneous hyperglycemia, glycosuria, hypoinsulinemia, and glucose intolerance were observed in some WBN/Kob rats, at about 9 months of age, and in all at the age of 17 months. Females did not present this pathology. Histopathologic examination of the pancreas revealed severe changes in male rats at the age of 3 months. Between 3 and 6 months of age a distinct infiltration of inflammatory cells was found around islets and among adjacent acinar cells. At the same time, marked fibrosis was seen around the pancreatic ducts and blood vessels. With advancing age the fibrous tissue gradually invaded extensive areas of the pancreas where also the islets became involved in fibrotic degeneration. At 17 months of age and later, an obvious decrease in islet number and size (less than 50 mu in diameter) was observed, even in relatively unaffected areas of the organ. Frequent bilateral cataracts began to appear at about 15 months of age. Opacities were first observed in the periphery of the lens, then increased rapidly in intensity and extended centripetally. Nineteen-month-old male rats were hypersensitive to exogenous insulin, but showed no significant decrease in blood glucose level when treated with oral tolbutamide. These results suggest that these rats suffered from a decreased insulinogenic response.
在一些WBN/Kob大鼠中，约9月龄时观察到自发性高血糖、糖尿、低胰岛素血症和葡萄糖不耐受，17月龄时所有大鼠均出现这些情况。雌性大鼠未出现这种病理状况。对胰腺进行组织病理学检查发现，3月龄雄性大鼠有严重病变。在3至6月龄之间，在胰岛周围和相邻腺泡细胞之间发现明显的炎性细胞浸润。同时，在胰管和血管周围可见明显纤维化。随着年龄增长，纤维组织逐渐侵入胰腺的广泛区域，胰岛也出现纤维化变性。在17月龄及以后，即使在该器官相对未受影响的区域，也观察到胰岛数量和大小明显减少（直径小于50微米）。约15月龄时开始频繁出现双侧白内障。混浊首先在晶状体周边观察到，然后强度迅速增加并向中心扩展。19月龄雄性大鼠对外源性胰岛素过敏，但口服甲苯磺丁脲治疗时血糖水平无显著下降。这些结果表明这些大鼠存在胰岛素生成反应降低的情况。
