Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China.
National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China.
Nutrients. 2021 Dec 27;14(1):99. doi: 10.3390/nu14010099.
The number of depressed people has increased worldwide. Dysfunction of the gut microbiota has been closely related to depression. The mechanism by which jasmine tea ameliorates depression via the brain-gut-microbiome (BGM) axis remains unclear. Here, the effects of jasmine tea on rats with depressive-like symptoms via the gut microbiome were investigated. We first established a chronic unpredictable mild stress (CUMS) rat model to induce depressive symptoms and measured the changes in depression-related indicators. Simultaneously, the changes in gut microbiota were investigated by 16S rRNA sequencing. Jasmine tea treatment improved depressive-like behaviors and neurotransmitters in CUMS rats. Jasmine tea increased the gut microbiota diversity and richness of depressed rats induced by CUMS. Spearman's analysis showed correlations between the differential microbiota ( and ) and depressive-related indicators (BDNF, GLP-1, and 5-HT in the hippocampus and cerebral cortex). Combined with the correlation analysis of gut microbiota, the result indicated that jasmine tea could attenuate depression in rats via the brain- gut-microbiome axis.
全球范围内抑郁人群数量有所增加。肠道微生物群功能障碍与抑郁症密切相关。然而，茉莉花茶通过脑-肠-微生物群（BGM）轴改善抑郁的机制尚不清楚。本研究通过肠道微生物群探讨了茉莉花茶对具有抑郁样症状大鼠的影响。我们首先建立了慢性不可预测轻度应激（CUMS）大鼠模型以诱导抑郁症状，并测量了与抑郁相关的指标变化。同时，通过 16S rRNA 测序研究了肠道微生物群的变化。结果表明，茉莉花茶可改善 CUMS 大鼠的抑郁样行为和神经递质。此外，茉莉花茶增加了 CUMS 诱导的抑郁大鼠的肠道微生物群多样性和丰富度。Spearman 分析显示，差异菌群（和）与与抑郁相关的指标（海马体和大脑皮层中的 BDNF、GLP-1 和 5-HT）之间存在相关性。结合肠道微生物群的相关性分析，结果表明茉莉花茶可以通过脑-肠-微生物群轴减轻大鼠的抑郁。
