Department of Microbiology & Molecular Genetics, Faculty of Life Sciences, The Women University, Multan, Pakistan.
Department of Botany, Faculty of Life Sciences, The Women University, Multan, Pakistan.
PLoS One. 2024 Sep 19;19(9):e0310728. doi: 10.1371/journal.pone.0310728. eCollection 2024.
Nanotechnology is a treasure trove of diversified themes which are endowed with broad applications. Herein, iron oxide (Fe2O3) nanoparticles were synthesized using Phyllanthus emblica aqueous fruit extract. The UV-Visible spectrum exhibited a surface plasmon resonance peak at 295nm. Fourier Transform Infrared Spectroscopy provided insight into the functional groups responsible for capping. X-ray diffraction analysis authenticated the crystalline nature of nanoparticles, while energy dispersive X-ray spectroscopy divulged that iron and oxygen comprised 54% of the nanoparticles' weight. Scanning electron microscopy established irregular morphology and agglomeration of nanoparticles. The Fe2O3 nanoparticles validated potent antimicrobial activity against 11 bacterial and 1 fungal isolates. The biggest zone of inhibition (23mm) was measured against S. enterica, whereas the smallest zone of inhibition (12mm) was documented against C. albicans and E. coli. The values for minimum inhibitory concentration ranged between 10 and 15μg/ml for all microbes. Nevertheless, no synergy was exhibited by the nanoparticles with any of the selected antibiotics (Fractional Inhibitory Concentration Index > 1). The photocatalytic dye degradation capability of Fe2O3 nanoparticles was assessed and the observations implied a significant increase in degradation of methyl red although, not of methylene blue. Furthermore, the nanoparticles were in possession of substantial antioxidant (34-38%) and anti-inflammatory (31-38%) capacities. Consequent upon the robust activities of P. emblica-mediated nanoparticles, these can be scrutinized for biomedical and environmental implementations in future.
纳米技术是一个多元化主题的宝库，具有广泛的应用。在此，使用余甘子水提物合成了氧化铁（Fe2O3）纳米粒子。紫外-可见光谱在 295nm 处显示出表面等离子体共振峰。傅里叶变换红外光谱提供了对负责封端的官能团的了解。X 射线衍射分析证实了纳米粒子的结晶性质，而能量色散 X 射线能谱揭示了铁和氧占纳米粒子重量的 54%。扫描电子显微镜确定了纳米粒子的不规则形态和团聚。Fe2O3 纳米粒子对 11 种细菌和 1 种真菌分离物表现出强大的抗菌活性。对肠炎沙门氏菌的最大抑制区（23mm），而对白色念珠菌和大肠杆菌的最小抑制区（12mm）。所有微生物的最小抑制浓度值在 10 到 15μg/ml 之间。然而，纳米粒子与任何选定的抗生素都没有表现出协同作用（分数抑制浓度指数>1）。评估了 Fe2O3 纳米粒子的光催化染料降解能力，观察结果表明，尽管亚甲基蓝的降解没有明显增加，但甲基红的降解显著增加。此外，纳米粒子具有相当大的抗氧化（34-38%）和抗炎（31-38%）能力。鉴于余甘子介导的纳米粒子具有强大的活性，可以在未来对其进行生物医学和环境应用的研究。
