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一种用于动态心脏监测的可重构和顺应性液体传感器。

A reconfigurable and conformal liquid sensor for ambulatory cardiac monitoring.

机构信息

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.

出版信息

Nat Commun. 2024 Oct 1;15(1):8492. doi: 10.1038/s41467-024-52462-8.

Abstract

The severe mismatch between solid bioelectronics and dynamic biological tissues has posed enduring challenges in the biomonitoring community. Here, we developed a reconfigurable liquid cardiac sensor capable of adapting to dynamic biological tissues, facilitating ambulatory cardiac monitoring unhindered by motion artifacts or interference from other biological activities. We employed an ultrahigh-resolution 3D scanning technique to capture tomographic images of the skin on the wrist. Then, we established a theoretical model to gain a deep understanding of the intricate interaction between our reconfigurable sensor and dynamic biological tissues. To properly elucidate the advantages of this sensor, we conducted cardiac monitoring alongside benchmarks such as the electrocardiogram. The liquid cardiac sensor was demonstrated to produce stable signals of high quality (23.1 dB) in ambulatory settings.

摘要

固液相电子学之间的严重不匹配给生物监测领域带来了持久的挑战。在这里,我们开发了一种可重构的液体心脏传感器,能够适应动态生物组织,实现不受运动伪影或其他生物活动干扰的可移动心脏监测。我们采用超分辨率 3D 扫描技术来获取手腕皮肤的层析图像。然后,我们建立了一个理论模型,深入了解我们的可重构传感器与动态生物组织之间的复杂相互作用。为了正确阐明这种传感器的优势,我们与心电图等基准一起进行了心脏监测。该液体心脏传感器在可移动环境中产生了稳定的高质量信号(23.1dB)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fb9/11445489/0a133ab672c8/41467_2024_52462_Fig1_HTML.jpg

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