Lan Tian, Lu Yunyan, He Jiawei, Zhan Chenni, Wang Xiaojia, Shao Xiying, Hu Zujian
Department of Breast Surgery, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China.
Department of Cardiology, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China.
iScience. 2024 Sep 25;27(10):111045. doi: 10.1016/j.isci.2024.111045. eCollection 2024 Oct 18.
This study was to assess the burden, trends, and risk factors associated with female breast cancer from 1990 to 2021 based on the Global Burden of Disease (GBD) 2021 study. In 2021, there were 20.32 million prevalent cases, 2.08 million incident cases, 0.66 million death cases, and 20.26 million disability-adjusted life years (DALYs). It presented an ascending trend in the age-standardized rates of prevalence and incidence over the past 32 years. The age-standardized DALYs rate (ASDR) increased slightly during 2012-2021. The DALYs increase was primarily driven by population aging and growth. High red meat intake accounted for the highest proportion of ASDR. Breast cancer burden attributed to metabolic risks increased, especially in the regions with low social-development index (SDI) and limited health systems. Dietary, behavior, and metabolic risk factors should be controlled to diminish breast cancer burden, especially in countries with lower SDI.
本研究基于《2021年全球疾病负担（GBD）研究》评估1990年至2021年期间与女性乳腺癌相关的负担、趋势和风险因素。2021年，有2032万例现患病例、208万例新发病例、66万例死亡病例以及2026万伤残调整生命年（DALYs）。在过去32年中，年龄标准化患病率和发病率呈上升趋势。2012年至2021年期间，年龄标准化伤残调整生命年率（ASDR）略有上升。伤残调整生命年的增加主要由人口老龄化和增长推动。红肉摄入量高占年龄标准化伤残调整生命年率的比例最高。归因于代谢风险的乳腺癌负担增加，尤其是在社会发展指数（SDI）较低且卫生系统有限的地区。应控制饮食、行为和代谢风险因素以减轻乳腺癌负担，尤其是在社会发展指数较低的国家。
