Vogt H J, Heller W D, Borelli S
Fertil Steril. 1986 Jan;45(1):106-10. doi: 10.1016/s0015-0282(16)49106-5.
The possible effects of cigarette smoking on sperm quality were investigated in a blind study of 333 healthy male volunteers 19 to 40 years of age. All subjects with clinically proven abnormalities, operations, or inflammatory diseases of the genital organs, exposure to radiation exceeding routine x-ray examination, or medication were excluded, and the data from 150 smokers, 37 ex-smokers, and 52 never-smokers were evaluated. There was a small but insignificant decrease in sperm density from never-smokers to ex-smokers and to smokers. Eight smokers (6%) had sperm counts less than 1 X 10(6)/ml, whereas none of the ex-smokers or never-smokers fell into this category. This difference, however, is not statistically significant (P = 0.084). No statistically significant effect of smoking habits on sperm density, motility, and morphologic features was detected. It is concluded that smoking does not affect the motility and morphologic features of sperm in healthy adult men. The diminished sperm density in heavy smokers may be related to factors associated with smoking.
在一项针对333名年龄在19至40岁的健康男性志愿者的盲法研究中，调查了吸烟对精子质量可能产生的影响。所有患有经临床证实的生殖器官异常、手术史、炎症性疾病、接受超过常规X光检查剂量辐射或正在服药的受试者均被排除在外，对150名吸烟者、37名既往吸烟者和52名从不吸烟者的数据进行了评估。从不吸烟者到既往吸烟者再到吸烟者，精子密度有轻微但不显著的下降。8名吸烟者（6%）的精子计数低于1×10⁶/ml，而既往吸烟者和从不吸烟者中均无此类情况。然而，这种差异无统计学意义（P = 0.084）。未检测到吸烟习惯对精子密度、活力和形态特征有统计学意义的影响。得出的结论是，吸烟不会影响健康成年男性精子的活力和形态特征。重度吸烟者精子密度降低可能与吸烟相关的因素有关。
