Liu Yang, Huang Xuan, Li Chuang, Deng Ping, Zhang Xu, Hu Yan, Dai Qiuzhong
Hunan Institute of Animal Husbandry and Veterinary Medicine, Changsha 410131, China.
Antioxidants (Basel). 2024 Sep 30;13(10):1190. doi: 10.3390/antiox13101190.
Oxidative stress is a major factor that limits the development of the poultry industry. Ferulic acid (FA) has an antioxidant effect in birds, but the mechanism is not fully understood. In this study, we stimulated oxidative stress in 28-day-old female Linwu ducks by lipopolysaccharide (LPS) and fed them a diet supplemented with FA for 28 days. Results showed that FA alleviated LPS-induced growth performance regression, oxidative stress, and microbiota imbalance in ducks. An integrated metagenomics and metabolomics analysis revealed that , , , and could be the biomarkers in the antioxidant effect of FA, which interacted with dihydro-3-coumaric acid, L-phenylalanine, and 13(S)-HODE, and regulated the phenylalanine metabolism and PPAR signaling pathway. This study revealed the mechanism of the antioxidant effect of FA, which provided evidence of applying FA as a new antioxidant in commercial duck production.
氧化应激是限制家禽业发展的一个主要因素。阿魏酸（FA）在禽类中具有抗氧化作用，但其机制尚未完全明确。在本研究中，我们用脂多糖（LPS）刺激28日龄雌性临武鸭产生氧化应激，并给它们喂食添加了FA的日粮28天。结果表明，FA缓解了LPS诱导的鸭子生长性能衰退、氧化应激和微生物群失衡。宏基因组学和代谢组学的综合分析表明， 、 、 和 可能是FA抗氧化作用的生物标志物，它们与二氢-3-香豆酸、L-苯丙氨酸和13(S)-羟基十八碳二烯酸相互作用，并调节苯丙氨酸代谢和PPAR信号通路。本研究揭示了FA抗氧化作用的机制，为在商品鸭生产中应用FA作为新型抗氧化剂提供了依据。
