Yan Yu, Lin Hong, He Zhiyao, Wang Ling
Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Department of Clinical Pharmacy and Pharmacy Administration, West China School of Pharmacy, Sichuan University, Chengdu, China.
Front Oncol. 2024 Oct 25;14:1354235. doi: 10.3389/fonc.2024.1354235. eCollection 2024.
The relationship between serum uric acid (SUA) levels and prostate cancer (PCa) remains controversial. This cross-sectional study investigated the association between SUA levels and PCa incidence.
A total of 9,776 participants aged ≥40 from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2020 were included, 503 of whom had PCa. Weighted univariate logistic regression, multivariate logistic regression, and smooth-fitting curve analyses were used to analyze the association between SUA and PCa incidence. Concurrently, the fitted smoothing curves were used to explore the potential non-linear relationships. If non-linearity was observed, a recursive algorithm further calculated the inflection point.
Three models were used to analyze the correlation between SUA levels and PCa incidence. All regression models demonstrated a negative correlation between SUA levels and PCa incidence (model 1: OR = 0.88, 95% CI=0.80-0.97; model 2: OR = 0.87, 95% CI=0.80-0.96; model 3: OR = 0.87, 95% CI=0.78-0.96). According to the trend test, with increasing SUA, the risk of PCa showed a downward trend (three models P for trend = 0.037, 0.015, 0.016). According to the subgroup analysis, a significant negative correlation between SUA and PCa was detected in individuals aged >60 years, non-Hispanic whites, those of other races, and those with hypertension. Moreover, the association between SUA and PCa followed a U-shaped curve among participants without hypertension, and the inflection point of SUA was 5.1 mg/dl.
This cross-sectional study revealed a negative relationship between SUA levels and the risk of PCa, particularly in specific demographic groups. These findings offer a fresh perspective on the role of SUA in PCa patients, potentially paving the way for new approaches for the prevention and treatment of PCa. However, further studies are necessary to validate these findings.
血清尿酸（SUA）水平与前列腺癌（PCa）之间的关系仍存在争议。这项横断面研究调查了SUA水平与PCa发病率之间的关联。
纳入了2007年至2020年美国国家健康与营养检查调查（NHANES）中9776名年龄≥40岁的参与者，其中503人患有PCa。采用加权单因素逻辑回归、多因素逻辑回归和平滑拟合曲线分析来分析SUA与PCa发病率之间的关联。同时，使用拟合的平滑曲线来探索潜在的非线性关系。如果观察到非线性，递归算法会进一步计算拐点。
使用三个模型分析SUA水平与PCa发病率之间的相关性。所有回归模型均显示SUA水平与PCa发病率呈负相关（模型1：OR = 0.88，95%CI = 0.80 - 0.97；模型2：OR = 0.87，95%CI = 0.80 - 0.96；模型3：OR = 0.87，95%CI = 0.78 - 0.96）。根据趋势检验，随着SUA升高，PCa风险呈下降趋势（三个模型趋势检验P值分别为0.037、0.015、0.016）。根据亚组分析，在年龄>60岁的个体、非西班牙裔白人、其他种族个体以及患有高血压的个体中，检测到SUA与PCa之间存在显著负相关。此外，在无高血压的参与者中，SUA与PCa之间的关联呈U形曲线，SUA的拐点为5.1mg/dl。
这项横断面研究揭示了SUA水平与PCa风险之间的负相关关系，尤其是在特定人群中。这些发现为SUA在PCa患者中的作用提供了新的视角，可能为PCa的预防和治疗新方法铺平道路。然而，需要进一步研究来验证这些发现。
