Visan Anita Ioana, Cristescu Rodica
National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Ilfov, Romania.
Pharmaceutics. 2023 Aug 29;15(9):2227. doi: 10.3390/pharmaceutics15092227.
Therapeutic polysaccharide-based coatings have recently emerged as versatile strategies to transform a conventional medical implant into a drug delivery system. However, the translation of these polysaccharide-based coatings into the clinic as drug delivery systems still requires a deeper understanding of their drug degradation/release profiles. This claim is supported by little or no data. In this review paper, a comprehensive description of the benefits and challenges generated by the polysaccharide-based coatings is provided. Moreover, the latest advances made towards the application of the most important representative coatings based on polysaccharide types for drug delivery are debated. Furthermore, suggestions/recommendations for future research to speed up the transition of polysaccharide-based drug delivery systems from the laboratory testing to clinical applications are given.
基于治疗性多糖的涂层最近已成为将传统医疗植入物转变为药物递送系统的通用策略。然而，将这些基于多糖的涂层作为药物递送系统应用于临床仍需要更深入地了解其药物降解/释放特性。这一说法缺乏数据支持或几乎没有数据支持。在这篇综述论文中，对基于多糖的涂层所带来的益处和挑战进行了全面描述。此外，还讨论了基于多糖类型的最重要代表性涂层在药物递送应用方面取得的最新进展。此外，还给出了关于未来研究的建议，以加速基于多糖的药物递送系统从实验室测试向临床应用的转变。
