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病例报告：喉肥厚性扁平苔藓罕见病例。

Case report: Rare case of laryngeal hypertrophic lichen planus.

作者信息

Kayser Elise, Thomas Jacques, Cortese Sophie, Beulque Emilie, Dolivet Gilles, Mastronicola Romina

机构信息

Institut de Cancérologie de Lorraine, 6 avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France.

Institut de Cancérologie de Lorraine, 6 avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France.

出版信息

Int J Surg Case Rep. 2025 Jan;126:110809. doi: 10.1016/j.ijscr.2024.110809. Epub 2024 Dec 30.

DOI:10.1016/j.ijscr.2024.110809
PMID:39753063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11755077/
Abstract

INTRODUCTION AND IMPORTANCE

Lichen planus is an inflammatory and chronic disease with multifactorial causes. Hypertrophic subtype of lichen planus is an extremely rare lesion when found in the larynx. This article describes the case of a man with such a lesion.

CASE PRESENTATION

A 54-year-old man presented after respiratory distress with a suspicious mass on the left hemilarynx. The patient consumed a lot of tobacco and alcohol. He underwent nasofibroscopy, CT scan and numerous direct laryngoscopies with biopsy. Histopathological analysis finally revealed a mucosal hypertrophic lichen planus. Nowadays, the patient has undergone a partial laryngectomy.

CLINICAL DISCUSSION

Lichen planus is a chronic immune disease with multifactorial causes like stress or genetic susceptibility, for example. Presentations may vary, and histological features include hyperkeratosis and lymphocytic infiltration, which could be the primary cause of tissue damage. Hypertrophic lichen planus is an extremely rare laryngeal lesion, and there are few examples of how it is treated. As in topical treatments for other types of lichen planus, corticosteroids may be helpful. In addition, the potential carcinogenic transformation of this type of lesion is not well known, and follow-up care is therefore required.

CONCLUSION

A patient presented with a hypertrophic lichen planus lesion in the larynx, which is an extremely rare location. Thus far, he has undergone surgery to treat it.

摘要

引言与重要性

扁平苔藓是一种病因多因素的慢性炎症性疾病。扁平苔藓的肥厚型在喉部极为罕见。本文描述了一名患有此类病变的男性病例。

病例介绍

一名54岁男性因呼吸窘迫就诊，左半喉有可疑肿物。该患者大量吸烟饮酒。他接受了鼻纤维镜检查、CT扫描以及多次直接喉镜检查并活检。组织病理学分析最终显示为黏膜肥厚型扁平苔藓。目前，该患者已接受部分喉切除术。

临床讨论

扁平苔藓是一种病因多因素的慢性免疫疾病，如压力或遗传易感性等。其表现可能各异，组织学特征包括角化过度和淋巴细胞浸润，这可能是组织损伤的主要原因。肥厚型扁平苔藓是一种极为罕见的喉部病变，关于其治疗方法的实例很少。与其他类型扁平苔藓的局部治疗一样，皮质类固醇可能会有帮助。此外，这种类型病变的潜在致癌转化情况尚不清楚，因此需要进行随访。

结论

一名患者喉部出现肥厚型扁平苔藓病变，这是一个极为罕见的部位。到目前为止，他已接受手术治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/de49632e832c/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/370ba79be462/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/5217a6ed5d69/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/e32c8395bd2b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/22b96bb6f926/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/66e222d65ae0/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/0fe6bf2e1127/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/de49632e832c/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/370ba79be462/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/5217a6ed5d69/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/e32c8395bd2b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/22b96bb6f926/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/66e222d65ae0/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/0fe6bf2e1127/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab9d/11755077/de49632e832c/gr7.jpg

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本文引用的文献

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A Case of Linear Hypertrophic Lichen Planus in a Pediatric Patient.一名儿童患者的线状肥厚性扁平苔藓病例。
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Hypertrophic Lichen Planus: An Up-to-Date Review and Differential Diagnosis.肥厚性扁平苔藓：最新综述与鉴别诊断。
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Hypertrophic lichen planus on lip mimicking SCC.唇部肥厚性扁平苔藓酷似鳞状细胞癌。
Clin Case Rep. 2022 Aug 8;10(8):e6191. doi: 10.1002/ccr3.6191. eCollection 2022 Aug.
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Identification of putative laryngeal and pharyngeal lichen planus lesions: An endoscopic preliminary evaluation in 16 patients.疑似喉和咽扁平苔藓病变的识别：16例患者的内镜初步评估
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