Horowitz B, Stryker M H, Waldman A A, Woods K R, Gass J D, Drago J
Vox Sang. 1985;48(3):150-5. doi: 10.1111/j.1423-0410.1985.tb00162.x.
The red blood cells of blood stored in containers made of polyvinylchloride (PVC) film are osmotically more stable and lose on average about 1/3 less hemoglobin than when blood is stored in another plastic [poly-(ethylene-co-ethyl acrylate); EEA]. The stability of uniform volumes of stored red blood cells varies directly with PVC surface area, whereas changes in EEA surface area have comparatively little or no effect. PVC contains high concentrations of the plasticizer, diethylhexylphthalate (DEHP), known to migrate into blood and to have a high potential for toxicity. To determine if DEHP could be the red cell stabilizing agent in PVC, whole blood was stored in containers made from EEA into which was incorporated varying amounts of DEHP. Incorporation of DEHP into EEA significantly reduced erythrocyte osmotic fragility (p = 0.01). The degree of reduced fragility correlated with the level of DEHP in the cell phase implicating DEHP in PVC containers as the stabilizing agent for red cells.
储存在由聚氯乙烯（PVC）薄膜制成的容器中的血液，其红细胞在渗透压方面更稳定，与储存在另一种塑料[聚（乙烯 - 共 - 丙烯酸乙酯）；EEA]中的血液相比，平均血红蛋白损失约少1/3。相同体积储存的红细胞的稳定性与PVC表面积成正比，而EEA表面积的变化影响相对较小或没有影响。PVC含有高浓度的增塑剂邻苯二甲酸二乙基己酯（DEHP），已知其会迁移到血液中且具有很高的毒性潜力。为了确定DEHP是否可能是PVC中红细胞的稳定剂，将全血储存在由EEA制成的容器中，其中加入了不同量的DEHP。将DEHP加入EEA中可显著降低红细胞渗透脆性（p = 0.01）。脆性降低的程度与细胞相中DEHP的水平相关，这表明PVC容器中的DEHP是红细胞的稳定剂。
