Pappalettera Chiara, Fabbrocino Anna, Miraglia Francesca, Rossini Paolo Maria, Vecchio Fabrizio
Brain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Rome, Italy.
Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Como, Italy.
Geroscience. 2025 Jan 31. doi: 10.1007/s11357-025-01545-5.
In an era marked by a rapidly aging global population, delving into the intricate neurophysiological changes that accompany the aging process assumes paramount importance. This narrative review offers a comprehensive exploration of the intricate relationship between electromagnetic neuromodulation and electroencephalography (EEG) within the context of aging. Moreover, it showed the promising landscape of non-invasive neuromodulation techniques, encompassing established methodologies like transcranial magnetic stimulation (TMS) and transcranial direct and alternating current stimulation (tDCS/tACS). These modalities are analyzed for their potential to shape EEG marks in the aging population. These associations not only could broaden our understanding of the aging brain but could also suggest exciting scenarios for therapeutic interventions and cognitive enhancement among the elderly. Consequently, the comprehension of these mechanisms emerges as a critical key player for the development of precisely tailored interventions, aimed at mitigating age-associated cognitive decline and supporting robust brain health in the elderly.
在一个全球人口迅速老龄化的时代，深入研究衰老过程中伴随的复杂神经生理变化至关重要。这篇叙述性综述全面探讨了衰老背景下电磁神经调节与脑电图（EEG）之间的复杂关系。此外，它展示了非侵入性神经调节技术的广阔前景，包括经颅磁刺激（TMS）以及经颅直流电刺激和经颅交流电刺激（tDCS/tACS）等既定方法。分析了这些方式对老年人群脑电图特征的塑造潜力。这些关联不仅能拓宽我们对衰老大脑的理解，还可能为老年人的治疗干预和认知增强带来令人兴奋的前景。因此，理解这些机制成为制定精准干预措施的关键因素，旨在减轻与年龄相关的认知衰退并支持老年人强健的大脑健康。
