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化学组3中的α,β-不饱和直链和支链脂肪族伯醇、醛、酸和酯用作所有动物物种的调味剂时的安全性和有效性。

Safety and efficacy of α,β-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species.

出版信息

EFSA J. 2016 Jun 24;14(6):e04512. doi: 10.2903/j.efsa.2016.4512. eCollection 2016 Jun.

Abstract

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 43 compounds belonging to chemical group 3 (α,β-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters) when used as feed flavourings for all animal species and categories. They are currently authorised as flavours in food. This opinion concerns 17 compounds from this group. The FEEDAP Panel established the following conclusions: geraniol [02.012] and citral [05.020] are safe for all target species at the proposed maximum use level of 25 mg/kg feed; farnesol [02.029], ()-nerol [02.058], geranyl acetate [09.011], geranyl butyrate [09.048], geranyl formate [09.076], geranyl propionate [09.128], neryl propionate [09.169], neryl formate [09.212], neryl acetate [09.213], neryl isobutyrate [09.424] and geranyl isobutyrate [09.431] are safe at the maximum proposed use level of 5 mg/kg feed for all target species; 2-methyl-2-pentenoic acid [08.055], ()-methylcrotonic acid [08.064], ethyl ()-deca-2,4-dienoate [09.260] and prenyl acetate [09.692] are safe at the proposed normal use levels of 1 mg/kg complete feed for all animal species. No safety concern would arise for the consumer from the use of these compounds up to the highest safe level in feeds. Hazards for skin and eye contact and respiratory exposure are recognised for the majority of the compounds under application. Most are classified as irritating to the respiratory system. The concentrations considered safe for the target species are unlikely to have detrimental effects on the terrestrial and fresh water environments. As all of the compounds under assessment are used in food as flavourings and their function in feed is essentially the same as that in food, no further demonstration of efficacy is necessary.

摘要

应欧盟委员会的要求,动物饲料添加剂及产品或物质专家小组(FEEDAP)被要求就化学类别3中的43种化合物(α,β-不饱和直链和支链脂肪族伯醇、醛、酸和酯)用作所有动物种类和类别的饲料调味剂时的安全性和有效性发表科学意见。它们目前被批准用作食品香料。本意见涉及该类别中的17种化合物。FEEDAP小组得出以下结论:香叶醇[02.012]和柠檬醛[05.020]在建议的最高使用水平25毫克/千克饲料下对所有目标物种都是安全的;法尼醇[02.029]、()-橙花醇[02.058]、乙酸香叶酯[09.011]、丁酸香叶酯[09.048]、甲酸香叶酯[09.076]、丙酸香叶酯[09.128]、丙酸橙花酯[09.169]、甲酸橙花酯[09.212]、乙酸橙花酯[09.213]、异丁酸橙花酯[09.424]和异丁酸香叶酯[09.431]在建议的最高使用水平5毫克/千克饲料下对所有目标物种都是安全的;2-甲基-2-戊烯酸[08.055]、()-甲基巴豆酸[08.064]、()-2,4-癸二烯酸乙酯[09.260]和乙酸异戊烯酯[09.692]在建议的正常使用水平1毫克/千克全价饲料下对所有动物种类都是安全的。在饲料中使用这些化合物直至最高安全水平,不会对消费者产生安全问题。在所应用的大多数化合物中,已确认存在皮肤和眼睛接触以及呼吸道暴露的危害。大多数被归类为对呼吸系统有刺激性。对目标物种而言被认为安全的浓度不太可能对陆地和淡水环境产生有害影响。由于所有评估的化合物都用作食品香料,且它们在饲料中的功能与在食品中的基本相同,因此无需进一步证明其有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/11847997/56991571b939/EFS2-14-e04512-g001.jpg

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