Dhar Rajib, Devi Arikketh
Cancer and Stem Cell Biology Laboratory, Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, 603203, India.
J Liq Biopsy. 2023 Nov 26;2:100129. doi: 10.1016/j.jlb.2023.100129. eCollection 2023 Dec.
Cancer is an unsolved health crisis worldwide. Extracellular vesicles (EVs) address this problem in a new way. In cancer, early detection is highly challenging, exosomes (a subpopulation of EVs, originating from endosomes) overcomes this limitation. In cancer, tumor-derived exosomes (TEXs) play a role as signaling molecules in cancer development and progression. TEXs provide detailed investigation for specific cancer biomarkers research. Exosomes heterogeneity (variation in exosomes size, exosomes origin, and inner molecular diversity) has led to complications in understanding and studying cancer liquid biopsies. Single exosome profiling and exosomes barcoding has helped in supporting and overcoming this limitation and has played a significant role in precision oncology. Exosomes barcoding is a promising interdisciplinary approach for screening cancers more specifically.
癌症是全球尚未解决的健康危机。细胞外囊泡（EVs）以一种新的方式解决了这个问题。在癌症中，早期检测极具挑战性，外泌体（EVs的一个亚群，起源于内体）克服了这一局限性。在癌症中，肿瘤来源的外泌体（TEXs）在癌症发展和进展中作为信号分子发挥作用。TEXs为特定癌症生物标志物研究提供了详细的研究方向。外泌体的异质性（外泌体大小、外泌体来源和内部分子多样性的变化）导致了在理解和研究癌症液体活检方面的复杂性。单个外泌体分析和外泌体条形码技术有助于支持和克服这一局限性，并在精准肿瘤学中发挥了重要作用。外泌体条形码技术是一种很有前景的跨学科方法，可更特异性地筛查癌症。
