Ravipati Shivani, Nath Arghya, Banerjee Sumitaksha, Kumar Harendra, Vasini Lella Vindhya, Sonar Swarup, Mukherjee Dattatreya
Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinna Avutapalle, Gannavaram, Andhra Pradesh, 521286, India.
ICMR-DHR Viral Research & Diagnostic Laboratory, Burdwan Medical College, Burdwan, India.
J Liq Biopsy. 2024 Jan 5;3:100139. doi: 10.1016/j.jlb.2024.100139. eCollection 2024 Mar.
Recent advances in cancer treatment emphasize the pivotal role of extracellular vesicles (EVs), especially exosomes (a subpopulation of EVs, originating from endosomes). Exosomes are signaling molecules in the cellular system. Its molecular signature displays the status of the cell (cell healthy or undergoing any clinical complication). Exosomes are frontiers of upcoming cancer theranostics era. This article highlighted cancer exosome complex interlink, the advantage of exosome-base liquid biopsy, the effectiveness of exosome-based cell-free therapy compared to cell therapy, complications of exosome research, and its solution. Hope, this article motivated cancer researchers to explore the exosome-based precision oncology era.
癌症治疗的最新进展凸显了细胞外囊泡（EVs）的关键作用，尤其是外泌体（EVs的一个亚群，起源于内体）。外泌体是细胞系统中的信号分子。其分子特征显示细胞的状态（细胞健康或正在经历任何临床并发症）。外泌体是即将到来的癌症诊疗时代的前沿领域。本文重点介绍了癌症外泌体的复杂相互联系、基于外泌体的液体活检的优势、与细胞疗法相比基于外泌体的无细胞疗法的有效性、外泌体研究的并发症及其解决方案。希望本文能激励癌症研究人员探索基于外泌体的精准肿瘤学时代。
