Goist K C, Sutker P B
Pharmacol Biochem Behav. 1985 May;22(5):811-4. doi: 10.1016/0091-3057(85)90532-5.
The present study was a direct experimental comparison of administering equivalent alcohol doses based on body weight and estimated total body water to 12 women and 12 men. Each subject participated in two experimental sessions separated by at least three days. Two doses of 95% ethanol were administered in a randomized, counterbalanced order: 0.66 ml/kg of body weight, and 1.2 ml/l of total body water. Women were tested during the midfollicular phase of their menstrual cycle when plasma concentrations of estrogen and progesterone have been found to be lower than other phases of the cycle. When given doses equated for body weight, women reached significantly higher peak blood alcohol concentrations than men. No sex differences were found when equivalent doses based on total body water were administered. This differential effect of dose determination was not reflected in self-reported levels of alcohol intoxication. The anthropometric equations used to estimate total body water provided a practical, reliable method for equating alcohol doses.
本研究对12名女性和12名男性按体重和估计的总体水给予等量酒精剂量进行了直接实验比较。每个受试者参加两个实验阶段，间隔至少三天。以随机、平衡的顺序给予两剂95%乙醇：0.66毫升/千克体重和1.2毫升/升总体水。女性在月经周期的卵泡中期接受测试，此时已发现雌激素和孕酮的血浆浓度低于周期的其他阶段。当给予按体重等量的剂量时，女性的血液酒精浓度峰值显著高于男性。给予基于总体水的等量剂量时未发现性别差异。剂量确定的这种差异效应未反映在自我报告的酒精中毒水平上。用于估计总体水的人体测量方程提供了一种实用、可靠的酒精剂量等量方法。
