Kirst H A, Dorman D E, Occolowitz J L, Jones N D, Paschal J W, Hamill R L, Szymanski E F
J Antibiot (Tokyo). 1985 May;38(5):575-86. doi: 10.7164/antibiotics.38.575.
The structure of the novel nucleoside antibiotic A201A has been determined by a combination of chemical and spectroscopic methods. It is composed of 6-dimethylaminopurine, 3-amino-3-deoxyribose, p-hydroxy-alpha-methylcinnamic acid, a novel unsaturated hexofuranose and 3,4-di-O-methylrhamnose. Structures have also been assigned to several related minor factors simultaneously isolated from the fermentation broth. These unique nucleosides have very interesting similarities and differences in structure with the known antibiotics puromycin and hygromycin A.
新型核苷抗生素A201A的结构已通过化学和光谱方法相结合的方式确定。它由6-二甲基氨基嘌呤、3-氨基-3-脱氧核糖、对羟基-α-甲基肉桂酸、一种新型不饱和己呋喃糖和3,4-二-O-甲基鼠李糖组成。同时从发酵液中分离出的几种相关次要成分的结构也已确定。这些独特的核苷与已知抗生素嘌呤霉素和潮霉素A在结构上有非常有趣的异同之处。
