Padmavathi V, Ganesan Kavitha
Department of Biomedical Engineering, CEG Campus, Anna University, Chennai, 600025, India.
Sci Rep. 2025 Apr 22;15(1):13941. doi: 10.1038/s41598-025-98593-w.
This study introduces a novel hybrid framework for classifying COVID-19 severity using chest X-rays (CXR) and computed tomography (CT) scans by integrating Vision Transformers (ViT) with metaheuristic optimization techniques. The framework employs the Grey Wolf Optimizer (GWO) for hyperparameter tuning and Particle Swarm Optimization (PSO) for feature selection, leveraging the ViT model's self-attention mechanism to extract global and local image features crucial for severity classification. A multi-phase classification strategy refines predictions by progressively distinguishing normal, mild, moderate, and severe COVID-19 cases. The proposed GWO_ViT_PSO_MLP model achieves outstanding accuracy, with 99.14% for 2-class CXR classification and 98.89% for 2-class CT classification, outperforming traditional CNN-based approaches such as ResNet34 (84.22%) and VGG19 (93.24%). Furthermore, it demonstrates superior performance in multi-class severity classification, especially in differentiating challenging cases like mild and moderate infections. Compared to existing studies, this framework significantly improves accuracy and computational efficiency, highlighting its potential as a scalable and reliable solution for automated COVID-19 severity detection in clinical applications.
本研究引入了一种新颖的混合框架,通过将视觉Transformer(ViT)与元启发式优化技术相结合,利用胸部X光(CXR)和计算机断层扫描(CT)扫描对COVID-19严重程度进行分类。该框架采用灰狼优化器(GWO)进行超参数调整,采用粒子群优化(PSO)进行特征选择,利用ViT模型的自注意力机制提取对严重程度分类至关重要的全局和局部图像特征。一种多阶段分类策略通过逐步区分正常、轻度、中度和重度COVID-19病例来细化预测。所提出的GWO_ViT_PSO_MLP模型取得了出色的准确率,在二分类CXR分类中为99.14%,在二分类CT分类中为98.89%,优于基于传统卷积神经网络的方法,如ResNet34(84.22%)和VGG19(93.24%)。此外,它在多类严重程度分类中表现出卓越的性能,特别是在区分轻度和中度感染等具有挑战性的病例方面。与现有研究相比,该框架显著提高了准确率和计算效率,凸显了其作为临床应用中自动化COVID-19严重程度检测的可扩展且可靠解决方案的潜力。