Alobeedallah Hadeel, Cornell Bruce, Coster Hans
School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, 2006, Australia.
SDx Tethered Membranes Pty Ltd, Roseville, NSW, 2069, Australia.
J Membr Biol. 2025 Jun;258(3):213-224. doi: 10.1007/s00232-025-00346-3. Epub 2025 Apr 28.
In this study, we describe the effect of the noble gas, xenon on the electrical properties of tethered lipid bilayer membranes, (tBLMs), including the effect of xenon on the activation energy for electrical conduction through the tBLM. Such studies benefit from the stability of a tethered membrane given the wide range of temperatures that are scanned and the time required for these measurements. The results indicate that xenon increases the activation energy for electrical conduction through bilayers and decreases the average pore size that dominates the electrical conductance of the lipid bilayers at low voltages. Xenon possesses a high affinity for lipid membranes and is a potent general anaesthetic. Its anaesthetic potency is possibly associated with its effects on proteins embedded in the lipid membranes.
在本研究中，我们描述了稀有气体氙对拴系脂质双层膜（tBLMs）电学性质的影响，包括氙对通过tBLM进行电传导的活化能的影响。鉴于扫描的温度范围广泛以及这些测量所需的时间，此类研究受益于拴系膜的稳定性。结果表明，氙增加了通过双层膜进行电传导的活化能，并减小了在低电压下主导脂质双层膜电导的平均孔径。氙对脂质膜具有高亲和力，并且是一种强效的全身麻醉剂。其麻醉效力可能与其对嵌入脂质膜中的蛋白质的影响有关。
