合成细胞保存策略使其能够在使用点进行存储和激活。
Synthetic cell preservation strategies enable their storage and activation at the point of use.
作者信息
Gispert Ignacio, Elani Yuval
机构信息
Department of Chemical Engineering, Imperial College London, South Kensington, London SW7 2AZ, UK.
Fabricell Imperial College London, South Kensington, London SW7 2AZ, UK.
出版信息
Chem Commun (Camb). 2025 May 13. doi: 10.1039/d5cc00826c.
Synthetic cells encapsulating cell-free protein synthesis machinery are currently limited to laboratory use due to preservation challenges. They are typically produced and used immediately. We present drying methods for long-term ambient storage that preserve their integrity and functionality, enabling activation at the point-of-use, overcoming key barriers to their deployment in biotechnology.
由于保存方面的挑战，目前封装无细胞蛋白质合成机制的合成细胞仅限于实验室使用。它们通常是即产即用。我们提出了用于长期常温储存的干燥方法，该方法可保持其完整性和功能，使其能够在使用点被激活，克服了将其应用于生物技术领域的关键障碍。
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