Mehta N, Iyawe V I, Cummin A R, Bayley S, Saunders K B, Bennett E D
Clin Sci (Lond). 1985 Oct;69(4):377-82. doi: 10.1042/cs0690377.
We have measured aortic flow in the ascending aorta in man with a Bach-Simpson BVM 202 blood velocity meter, and aortic root diameter by M-mode echocardiography, and thus derived beat-to-beat cardiac output (Q). We tested the technique in 21 patients (53 comparisons) with various cardiovascular problems against a thermodilution method, and in four normal subjects at rest and two levels of exercise (50 and 100 W) against a nitrous oxide rebreathing method. We obtained excellent overall correlation in a range of 0.5-10 litres/min (r = 0.98, n = 77, sy,x = 0.48 litre/min), the formula for the least squares regression being: (Q Doppler) = 0.95 (Q Thermodilution/N2O) + 0.11 litre/min. The Doppler signal is sufficiently noise-free to obtain maximum acceleration of flow from the first derivative of velocity.
我们使用Bach-Simpson BVM 202血流速度仪测量了人体升主动脉中的血流，并通过M型超声心动图测量了主动脉根部直径，从而得出逐搏心输出量（Q）。我们针对热稀释法，在21例患有各种心血管疾病的患者中（进行了53次对比）对该技术进行了测试；针对氧化亚氮重复呼吸法，在4名静息状态的正常受试者以及两个运动水平（50瓦和100瓦）下对该技术进行了测试。在0.5 - 10升/分钟的范围内，我们获得了极佳的总体相关性（r = 0.98，n = 77，sy,x = 0.48升/分钟），最小二乘回归公式为：（多普勒法测得的Q）= 0.95（热稀释法/氧化亚氮法测得的Q）+ 0.11升/分钟。多普勒信号的无噪声程度足以从速度的一阶导数中获取最大血流加速度。
