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人工智能在细胞工程和分子生物学中的进展综述

Review on Advancement of AI in Cell Engineering and Molecular Biology.

作者信息

Swargiary Deepsikha, Saikia Abhipsha, Basumatary Devi, Borah Jagat C

机构信息

Chemical Biology Lab-I, Institute of Advanced Study in Science and Technology (IASST), Guwahati, Assam, India.

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.

出版信息

Methods Mol Biol. 2025;2952:169-192. doi: 10.1007/978-1-0716-4690-8_10.

Abstract

Artificial intelligence is emerging as an important domain in the scientific field with the potential to provide advancements in molecular biology and cell engineering to improve the quality of life of human beings. The convergence of AI and related technologies linked with biology can lower the technical and knowledge barriers in numerous areas, such as diagnostics and forecasting. Artificial intelligence (AI) and machine learning tools are revolutionizing life science research and biomedical applications. Examples include understanding ecosystems across space and time, designing new drugs, deciphering molecular data and biomedical images, and predicting the 3D structures of proteins. Cellular engineering is a new field that has arisen as biomedical engineering has moved from the organ and tissue level to the cellular and subcellular level. Through the automated and programmatically enabled finding of tissue-level patterns and design principles, AI presents a radically new paradigm for tissue engineering research.Molecular biology delves into the intricate mechanisms governing life at its most fundamental level-the molecular scale, exploring the structure, function, and interactions of biological molecules such as DNA, RNA, proteins, and lipids. AI has spearheaded remarkable advancements in molecular biology, fundamentally transforming numerous facets of research, including drug discovery, protein structure prediction, genomic analysis, drug repurposing, synthetic biology, and disease diagnosis and prognosis. Moreover, this chapter demonstrates the fundamental potentials of AI and their applications focusing on molecular biology and cellular engineering.

摘要

人工智能正在成为科学领域的一个重要领域,有潜力在分子生物学和细胞工程方面取得进展,以提高人类的生活质量。人工智能与相关生物技术的融合可以降低诊断和预测等众多领域的技术和知识壁垒。人工智能(AI)和机器学习工具正在彻底改变生命科学研究和生物医学应用。例如,理解跨时空的生态系统、设计新药、解读分子数据和生物医学图像,以及预测蛋白质的三维结构。随着生物医学工程从器官和组织层面发展到细胞和亚细胞层面,细胞工程应运而生。通过自动和程序化地发现组织层面的模式和设计原则,人工智能为组织工程研究提供了一种全新的范式。分子生物学深入研究生命最基本层面——分子尺度上的复杂机制,探索DNA、RNA、蛋白质和脂质等生物分子的结构、功能和相互作用。人工智能在分子生物学领域取得了显著进展,从根本上改变了研究的许多方面,包括药物发现、蛋白质结构预测、基因组分析、药物再利用、合成生物学以及疾病诊断和预后。此外,本章展示了人工智能的基本潜力及其在分子生物学和细胞工程方面的应用。

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