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Animal models of critical care illnesses: current reality, future directions.

作者信息

Fraser John F, Inoue Shigeaki, Yao Yongming, Osuchowski Marcin F

机构信息

Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.

Intensive Care Department, St Andrews War Memorial Hospital, Brisbane, Australia.

出版信息

Intensive Care Med Exp. 2025 Jun 25;13(1):65. doi: 10.1186/s40635-025-00776-2.

DOI:10.1186/s40635-025-00776-2
PMID:40560285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12198087/
Abstract
摘要

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本文引用的文献

1
Analysis of animal-to-human translation shows that only 5% of animal-tested therapeutic interventions obtain regulatory approval for human applications.动物到人体转化的分析表明,只有5%经过动物试验的治疗性干预措施获得了用于人体的监管批准。
PLoS Biol. 2024 Jun 13;22(6):e3002667. doi: 10.1371/journal.pbio.3002667. eCollection 2024 Jun.
2
Understanding the mechanisms of ventilator-induced lung injury using animal models.利用动物模型了解呼吸机诱导性肺损伤的机制。
Intensive Care Med Exp. 2023 Nov 27;11(1):82. doi: 10.1186/s40635-023-00569-5.
3
Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge.在 SARS-CoV-2 大流行期间连接动物和临床研究:一个新的老挑战。
EBioMedicine. 2021 Apr;66:103291. doi: 10.1016/j.ebiom.2021.103291. Epub 2021 Apr 1.
4
Organs-on-chips: into the next decade.芯片器官:迈向新的十年。
Nat Rev Drug Discov. 2021 May;20(5):345-361. doi: 10.1038/s41573-020-0079-3. Epub 2020 Sep 10.
5
Current gaps in sepsis immunology: new opportunities for translational research.脓毒症免疫学的当前差距:转化研究的新机遇。
Lancet Infect Dis. 2019 Dec;19(12):e422-e436. doi: 10.1016/S1473-3099(19)30567-5. Epub 2019 Oct 17.
6
Animal models for trauma research: what are the options?创伤研究的动物模型:有哪些选择?
Shock. 2009 Jan;31(1):3-10. doi: 10.1097/SHK.0b013e31817fdabf.