Jones D T, Thomson R J, Sears M R
Eur J Respir Dis. 1985 Sep;67(3):159-66.
Twenty-one patients with severe chronic irreversible airflow obstruction (FEV1 consistently less than 1.2 l) were allocated randomly to one of two training programmes designed to reduce respiratory disability or a placebo training control group. Daily structured physical exercise, twice daily inspiratory muscle training by resistive breathing, or daily placebo training were undertaken for 10 weeks, and the effects on lung function, exercise capacity, respiratory symptoms and psychological state compared. Maximal work achieved on a progressive bicycle exercise test was significantly increased in all groups (36%, 23% and 34% respectively) and global improvement in mood also occurred. There was no significant change in respiratory symptom score, static lung function tests or 12 min walking distance. Neither form of active treatment showed superiority over placebo training.
21例患有严重慢性不可逆气流阻塞（第一秒用力呼气容积持续低于1.2升）的患者被随机分配到两个旨在减轻呼吸功能障碍的训练项目组之一或一个安慰剂训练对照组。进行了为期10周的每日结构化体育锻炼、每日两次通过阻力呼吸进行吸气肌训练或每日安慰剂训练，并比较了其对肺功能、运动能力、呼吸道症状和心理状态的影响。在递增式自行车运动试验中，所有组达到的最大运动量均显著增加（分别为36%、23%和34%），情绪也有整体改善。呼吸道症状评分、静态肺功能测试或12分钟步行距离均无显著变化。两种积极治疗方式均未显示出优于安慰剂训练的效果。
