Scansetti G, Lamon S, Talarico S, Botta G C, Spinelli P, Sulotto F, Fantoni F
Int Arch Occup Environ Health. 1985;57(1):19-26. doi: 10.1007/BF00383542.
Twenty-six workers in a hard metal manufacturing plant were monitored by cobalt urinary and ambient air measurements during the first month after summer holidays. Cobalt determinations were performed utilizing AAS, with a preliminary chelation and extraction procedure for urinary samples. Almost all personal ambient air samples turned out to be under the cobalt dust TLV of 0.1 mg/m3. When restarting work after the holidays, urinary values did not differ from the control group. At the end of the first working week, urinary cobalt had increased four fold, then decreased to the original values on the following Monday before restarting work. Thereafter, the weekend was no longer sufficient to reduce the levels to normal urinary cobalt values. The values rose to the same level observed before the holidays, and dit not substantially decrease even after the weekend. End-shift urinary cobalt values showed a good relationship with present as well as with mean past exposure on the first and the fifth weekday, but the third day did not. The correlation was better with present exposure on Monday and with mean past exposure on Friday. The observed differences may be explained by the minor influence of recent exposure on present exposure on Monday. The highest values were found on Wednesday. We suggest the utilization of end-shift urinary cobalt determination as a measure of the present exposure on Monday, and of mean recent or preceding exposure on Friday.
在暑假后的第一个月，通过检测尿钴和工作场所空气钴含量对一家硬质合金制造工厂的26名工人进行了监测。采用原子吸收光谱法（AAS）测定钴含量，对尿样进行初步螯合和萃取处理。几乎所有的个人工作场所空气样本中的钴尘含量都低于0.1毫克/立方米的阈限值（TLV）。假期结束重新开始工作时，尿钴值与对照组没有差异。在第一个工作周结束时，尿钴含量增加了四倍，然后在接下来周一重新开始工作前降至原始值。此后，周末已不足以将尿钴水平降至正常。尿钴值升至假期前观察到的相同水平，即使在周末后也没有大幅下降。工作日结束时的尿钴值与第一个和第五个工作日的当前暴露量以及过去平均暴露量均呈现良好的相关性，但在第三天并非如此。周一与当前暴露量以及周五与过去平均暴露量之间的相关性更好。观察到的差异可能是由于周一近期暴露对当前暴露的影响较小。周三的尿钴值最高。我们建议将工作日结束时的尿钴测定作为周一当前暴露量的衡量指标，以及周五近期或之前平均暴露量的衡量指标。
